Noise Exposure and Near-Infrared Light

NCT ID: NCT03834714

Last Updated: 2022-04-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-02-18

Study Completion Date

2021-12-23

Brief Summary

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The primary objective of this work is to determine the effect noise has on the auditory system (both auditory health and performance) and also the degree to which the effect of pre-noise therapy such as Near Infrared (NIR) light can mitigate the effects of noise exposure.

Detailed Description

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Conditions

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Hearing Loss, Noise-Induced

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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Noise Stimulus and Infrared Light

All participants will receive noise stimulus at each of the 4 visits. In addition, they will receive infrared light therapy for 2 out of the 4 visits and sham infrared light therapy for the other 2 visits.

Group Type ACTIVE_COMPARATOR

Near Infrared Light

Intervention Type DEVICE

NIR Light Therapy will be administered with the Earlight Generation 1.4 device during 2 out of the 4 sessions. It will be administered to each ear individually for 30 minutes per ear.

Noise Stimulus

Intervention Type OTHER

Noise stimulus will be administered, open ear, to continuous broadband noise up to 25% of the allowable daily dose of noise per the AFI 48-127 Occupational Noise and Hearing Conservation Program.

Noise Stimulus and Sham

All participants will receive noise stimulus at each of the 4 visits. In addition, they will receive sham infrared light therapy for 2 out of the 4 visits and infrared light therapy for the other 2 visits.

Group Type SHAM_COMPARATOR

Noise Stimulus

Intervention Type OTHER

Noise stimulus will be administered, open ear, to continuous broadband noise up to 25% of the allowable daily dose of noise per the AFI 48-127 Occupational Noise and Hearing Conservation Program.

Sham Near Infrared Light

Intervention Type DEVICE

Sham NIR Light Therapy will be administered with the Earlight Generation 1.4 device during 2 out of the 4 sessions. It will be administered to each ear individually for 30 minutes per ear.

Interventions

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Near Infrared Light

NIR Light Therapy will be administered with the Earlight Generation 1.4 device during 2 out of the 4 sessions. It will be administered to each ear individually for 30 minutes per ear.

Intervention Type DEVICE

Noise Stimulus

Noise stimulus will be administered, open ear, to continuous broadband noise up to 25% of the allowable daily dose of noise per the AFI 48-127 Occupational Noise and Hearing Conservation Program.

Intervention Type OTHER

Sham Near Infrared Light

Sham NIR Light Therapy will be administered with the Earlight Generation 1.4 device during 2 out of the 4 sessions. It will be administered to each ear individually for 30 minutes per ear.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* 18-45 years old, male or female
* Pass hearing exam with a threshold of 25 decibels (dB) hearing or less, for each ear, for all frequencies tested from 500 Hz to 8000 Hz
* Normal otoscopic exam, otoacoustic emissions (OAEs), and middle ear function as demonstrated by a normal tympanogram
* Completion of a hearing history questionnaire

Exclusion Criteria

* Screening hearing test failure
* Pregnant females
* Adults unable to provide consent
* History of significant ear surgery
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Office of Naval Research (ONR)

FED

Sponsor Role collaborator

University of Miami

OTHER

Sponsor Role lead

Responsible Party

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Michael E. Hoffer

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Michael E Hoffer, MD

Role: PRINCIPAL_INVESTIGATOR

University of Miami

Locations

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U.S. Army Aeromedical Research Laboratory

Fort Rucker, Alabama, United States

Site Status

University of Miami Miller School of Medicine

Miami, Florida, United States

Site Status

Wright-Patterson Air Force Base

Wright-Patterson Air Force Base, Ohio, United States

Site Status

Countries

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United States

Other Identifiers

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GR014085

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

20181214

Identifier Type: -

Identifier Source: org_study_id

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