Regorafenib in Taiwan Metastatic Colorectal Cancer (mCRC) Patients

NCT ID: NCT03829852

Last Updated: 2021-07-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

716 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-02-11

Study Completion Date

2020-12-08

Brief Summary

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Regorafenib is currently the standard of care for refractory mCRC patients. Pivotal studies of regorafenib have proven the efficacy and safety, with a 28-day cycle (21 days on, 7 days off) and 160 mg dose given once daily.

In the clinic, patients often have some complicated condition. This study aims to perform retrospective medical chart review of mCRC patients who received regorafenib treatment in two medical centers in Taiwan to examine treatment effectiveness in the routine clinical practice setting.

Detailed Description

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Conditions

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Metastatic Colorectal Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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Regorafenib

Treatment was performed based on physician's discretion

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* mCRC patients who received at least one dose of regorafenib treatment

Exclusion Criteria

* \<=20 y/o
* Patients who did not receive regorafenib treatment will be excluded from the analysis
* Patients with incomplete medical records that are deemed ineligible for analysis by investigator
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chang Gung Memorial Hospital

OTHER

Sponsor Role collaborator

Koo Foundation Sun Yat-Sen Cancer Center

OTHER

Sponsor Role collaborator

Taipei Veterans General Hospital, Taiwan

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hao-Wei Teng, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Taipei Veterans General Hospital, Taiwan

Locations

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Taipei Veterans General Hospital

Taipei, , Taiwan

Site Status

Countries

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Taiwan

References

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Hsu HC, Huang KC, Chen WS, Jiang JK, Yang SH, Wang HS, Chang SC, Lan YT, Lin CC, Lin HH, Huang SC, Cheng HH, Yang TS, Chen CC, Chao Y, Teng HW. Preference criteria for regorafenib in treating refractory metastatic colorectal cancer are the small tumor burden, slow growth and poor/scanty spread. Sci Rep. 2021 Jul 28;11(1):15370. doi: 10.1038/s41598-021-94968-x.

Reference Type DERIVED
PMID: 34321583 (View on PubMed)

Other Identifiers

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2018-12-013BC

Identifier Type: -

Identifier Source: org_study_id

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