The Effect of Proprioception of Platelet Rich Plasma for Patients With Ankle Sprain

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-01

Study Completion Date

2024-12-31

Brief Summary

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Ankle sprain is a fairly common sports medicine clinic. In Taiwan at least 150,000 to 200,000 people will suffer from ankle sprains every years. Clinicians have been looking for ways to shorten treatment time and reduce discomfort. Platelet Rich Plasma(PRP) is an endogenous therapeutic technology that involved in regenerative medicine due to its potential to stimulate and accelerate tissue healing. PRP can release lots of growth factors like platelet-derived growth factor (PDGF),transforming Growth Factor Beta(TGF-β), vascular endothelial growth factor(VEGF),Epidermal growth factor(EGF) and insulin-like growth factor (IGF). Its use had been based on the theory that increased autologous platelets, that then yield high concentrations of growth factors and other proteins, will lead to increased healing of tendon and soft tissue on a cellular level. In addition, there is no objective evaluation after treatment, so that patients can not provide effective and accurate quantitative feedback. In this study, the investigators divided patients into three groups, respectively, general rehabilitation therapy, autologous PRP injection therapy, autologous PRP injection combined with general rehabilitation therapy.

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Detailed Description

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The investigators divided patients into three groups, respectively, general rehabilitation therapy, autologous PRP injection therapy, autologous PRP injection combined with general rehabilitation therapy randomly. The investigators also use the new ankle proprioception evaluation system and evaluation of clinical function after treatment. It is expected to establish another feasible and rapid treatment method for ankle sprain. Combined with high accuracy ankle body defect evaluation method, it is helpful to design proper treatment and rehabilitation strategy in the future so as to improve the rehabilitation of limbs Coordination and control capabilities.

Conditions

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Ankle Sprain 2Nd Degree Ankle Sprain 3Rd Degree

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Platelet rich plasma (PRP)

PRP injection only

Group Type EXPERIMENTAL

PRP

Intervention Type DRUG

The investigators draw 10cc of blood and concentrate the blood to get the platelet rich plasma

PRP+Rehabilitation

PRP injection combined with rehabilitation

Group Type EXPERIMENTAL

PRP+Rehabilitation

Intervention Type COMBINATION_PRODUCT

combine PRP and Rehabilitation

Rehabilitation

Rehabilitation treatment only

Group Type ACTIVE_COMPARATOR

Rehabilitation

Intervention Type OTHER

strengthening ex, posture training,...

Interventions

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PRP

The investigators draw 10cc of blood and concentrate the blood to get the platelet rich plasma

Intervention Type DRUG

Rehabilitation

strengthening ex, posture training,...

Intervention Type OTHER

PRP+Rehabilitation

combine PRP and Rehabilitation

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

* ankle sprain within one months
* Gr II or Gr III ankle sprain (anterior talus fibular ligament)by sonogram proved
* MMSE≥23
* could cooperate the examination of the test

Exclusion Criteria

* Hemianopsia or hemineglect any brain lesion such as cerebrum of cerebellum involved movement
* cancer victim
* pregnant If needed PRP treatment
* Liver cirrhosis
* Platelet \< 150000/UL
* Sepsis, Leukemia
* use anti-coagulation agents
* under hemodialysis

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No