Vitamin C for the Prevention of UTI in Women Who Undergo Elective GYN Surgeries
NCT ID: NCT03800667
Last Updated: 2019-07-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
EARLY_PHASE1
INTERVENTIONAL
2018-08-08
2019-07-12
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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Women on a vitamin C regimen
Women who are undergoing elective gynecological surgeries and who are randomized to take 1000 mg of vitamin C for one month,
Ascorbic Acid 1000 MG
1000 mg ascorbic acid (Vitamin C) for 1 month post-op after an elective gynecological surgery.
Women not taking vitamin C
Women who are undergoing elective gynecological surgeries and who are randomized not to take any vitamin C for one month.
No interventions assigned to this group
Interventions
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Ascorbic Acid 1000 MG
1000 mg ascorbic acid (Vitamin C) for 1 month post-op after an elective gynecological surgery.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
1. Nephrolithiasis
2. Congenital anomaly or neurogenic bladder
3. Allergy to ascorbic acid
4. Who require therapeutic anticoagulant medicine during the 6 weeks after surgery
5. Surgery did involve a fistula repair or a vaginal mesh removal
6. Positive Urinalysis in the PAU
7. Recurrent UTI's
8. Diabetes
9. G6PD
10. Hemochromatosis
11. Renal disorders
Patients already taking Vitamin C supplementation will also be excluded from the study.
18 Years
FEMALE
No
Sponsors
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American University of Beirut Medical Center
OTHER
Responsible Party
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Tony Bazi
MD
Principal Investigators
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Tony Bazi, MD
Role: PRINCIPAL_INVESTIGATOR
American University of Beirut Medical Center
Locations
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American University of Beirut Medical Center
Beirut, , Lebanon
Countries
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References
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Foxman B, Cronenwett AE, Spino C, Berger MB, Morgan DM. Cranberry juice capsules and urinary tract infection after surgery: results of a randomized trial. Am J Obstet Gynecol. 2015 Aug;213(2):194.e1-8. doi: 10.1016/j.ajog.2015.04.003. Epub 2015 Apr 13.
Ochoa-Brust GJ, Fernandez AR, Villanueva-Ruiz GJ, Velasco R, Trujillo-Hernandez B, Vasquez C. Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancy. Acta Obstet Gynecol Scand. 2007;86(7):783-7. doi: 10.1080/00016340701273189.
Carlsson S, Wiklund NP, Engstrand L, Weitzberg E, Lundberg JO. Effects of pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation and bacterial growth in urine. Nitric Oxide. 2001 Dec;5(6):580-6. doi: 10.1006/niox.2001.0371.
Trautner BW, Darouiche RO. Catheter-associated infections: pathogenesis affects prevention. Arch Intern Med. 2004 Apr 26;164(8):842-50. doi: 10.1001/archinte.164.8.842.
Barbosa-Cesnik C, Brown MB, Buxton M, Zhang L, DeBusscher J, Foxman B. Cranberry juice fails to prevent recurrent urinary tract infection: results from a randomized placebo-controlled trial. Clin Infect Dis. 2011 Jan 1;52(1):23-30. doi: 10.1093/cid/ciq073.
Hickling DR, Nitti VW. Management of recurrent urinary tract infections in healthy adult women. Rev Urol. 2013;15(2):41-8.
Wald HL, Ma A, Bratzler DW, Kramer AM. Indwelling urinary catheter use in the postoperative period: analysis of the national surgical infection prevention project data. Arch Surg. 2008 Jun;143(6):551-7. doi: 10.1001/archsurg.143.6.551.
Other Identifiers
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OGY.TB.09
Identifier Type: -
Identifier Source: org_study_id
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