Anogenital Distance Differences Between Transgender Males and Female Individuals
NCT ID: NCT03789331
Last Updated: 2019-04-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
150 participants
OBSERVATIONAL
2019-04-01
2020-03-15
Brief Summary
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Detailed Description
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Studies have shown alterations in anogenital distance associated with reproductive health and sexual orientation. For instance, shorter anogenital distance has been reported in boys with hypospadias and cryptorchidism. Men with reduced testicular volume have significantly shorter anogenital distance compared with controls. Increased anogenital distance has been indicated in girls with congenital adrenal hyperplasia.
The investigators hypothesized that a prenatal pathological androgenic environment, resulting in a longer anogenital distance, will be able to be associated with a higher risk of sexual orientation disorders like transsexualism. This cross-sectional study aimed to assess the anogenital distance measurement differences between transgender male persons and normal healthy female individuals.
Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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Transgender Male individuals
* Group Description: This group consists of transgender male individuals who come to the gynecology clinic for medico-legal evaluation before the sex reassignment surgery.
* Intervention: Anogenital distance measurement with a digital caliper in centimeters in the lithotomy position.
Anogenital distance measurement
The women were kindly asked to lay down in the lithotomy position with their thighs at 45° to the examination table. A digital caliper (Mitutoyo 500-752-10 ABSOLUTE Digimatic Coolant Proof Caliper 0-150mm / 0-6", Mitutoyo Corporation, Japan) was used to measure anogenital distance.
Anogenital distance anus to clitoris: will be measured in centimeters from the anterior clitoral surface to the center of the anus.
Anogenital distance anus to fourchette: will be measured in centimeters from the posterior fourchette to the center of the anus.
Two investigators who were blind to the gynecological status of the women will measure each distance three times, and the mean value of the six measurements of each anogenital distance will be used.
Normal healthy female individuals
* Group Description: Healthy women with normal sexual orientation.
* Intervention: (The same) Anogenital distance measurement with a digital caliper in centimeters in the lithotomy position.
Anogenital distance measurement
The women were kindly asked to lay down in the lithotomy position with their thighs at 45° to the examination table. A digital caliper (Mitutoyo 500-752-10 ABSOLUTE Digimatic Coolant Proof Caliper 0-150mm / 0-6", Mitutoyo Corporation, Japan) was used to measure anogenital distance.
Anogenital distance anus to clitoris: will be measured in centimeters from the anterior clitoral surface to the center of the anus.
Anogenital distance anus to fourchette: will be measured in centimeters from the posterior fourchette to the center of the anus.
Two investigators who were blind to the gynecological status of the women will measure each distance three times, and the mean value of the six measurements of each anogenital distance will be used.
Interventions
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Anogenital distance measurement
The women were kindly asked to lay down in the lithotomy position with their thighs at 45° to the examination table. A digital caliper (Mitutoyo 500-752-10 ABSOLUTE Digimatic Coolant Proof Caliper 0-150mm / 0-6", Mitutoyo Corporation, Japan) was used to measure anogenital distance.
Anogenital distance anus to clitoris: will be measured in centimeters from the anterior clitoral surface to the center of the anus.
Anogenital distance anus to fourchette: will be measured in centimeters from the posterior fourchette to the center of the anus.
Two investigators who were blind to the gynecological status of the women will measure each distance three times, and the mean value of the six measurements of each anogenital distance will be used.
Eligibility Criteria
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Inclusion Criteria
* Healthy transgender male individuals whose gender identity (Male) are different from their birth-assigned sex (Female). The participants will be invited to the study at the time of medico-legal evaluation before the sex reassignment surgery.
Exclusion Criteria
* Other sexual orientation disorders. (Lesbian, Gay, Bisexual, Queer, Intersex, or Asexual persons)
18 Years
50 Years
FEMALE
Yes
Sponsors
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Uludag University
OTHER
Responsible Party
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Adnan Orhan
Obstetrician and Gynecologist (M.D. and researcher)
Principal Investigators
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Adnan Orhan, M.D.
Role: STUDY_DIRECTOR
Uludag University, Department of Obstetrics and Gynecology
Locations
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Uludag University Hospital, Department of Obstetrics and Gynecology
Bursa, Ozluce, Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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References
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Wu Y, Zhong G, Chen S, Zheng C, Liao D, Xie M. Polycystic ovary syndrome is associated with anogenital distance, a marker of prenatal androgen exposure. Hum Reprod. 2017 Apr 1;32(4):937-943. doi: 10.1093/humrep/dex042.
Sanchez-Ferrer ML, Mendiola J, Hernandez-Penalver AI, Corbalan-Biyang S, Carmona-Barnosi A, Prieto-Sanchez MT, Nieto A, Torres-Cantero AM. Presence of polycystic ovary syndrome is associated with longer anogenital distance in adult Mediterranean women. Hum Reprod. 2017 Nov 1;32(11):2315-2323. doi: 10.1093/humrep/dex274.
Other Identifiers
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UU-SUAM-2017-21/37
Identifier Type: -
Identifier Source: org_study_id
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