Local Ablative Therapy For Hormone Sensitive Oligometastatic Prostate Cancer

NCT ID: NCT03784755

Last Updated: 2025-11-20

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 409 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-11-15
• Study Completion Date: 2033-07-30

Brief Summary

The purpose of this study is to compare the effects of ablative therapy (radiation or surgery) to all sites of disease combined with standard treatments on prostate cancer, compared to the standard or usual treatments used to treat this disease.

Detailed Description

The standard or usual treatment for this disease is systemic therapy, which includes androgen deprivation therapy (ADT) with or without chemotherapy or hormone therapy. Additionally, for some patients with specific disease features, standard treatment may also include ablative treatment (radiation or surgery) of the prostate gland if this was not completed prior to enrolling into this study.

Ablative Therapy is a procedure used to destroy cancer cells and tissue. In this study Stereotactic Body Radiation Therapy (SBRT) or surgery will be used to destroy prostate cancer metastases. It is not clear if ablative therapy (SBRT or surgery) to all sites of disease used in combination with standard systemic therapy can offer better results than standard treatment alone.

Conditions

Prostate Cancer Metastatic

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Arm 1 (standard of care)

Standard systemic therapy

+ Ablative therapy to untreated prostate primary for patients with low volume metastatic disease burden

Group Type: ACTIVE_COMPARATOR

Standard of care

Intervention Type: OTHER

Patients continue to receive their current planned systemic therapy at the discretion of the treating physician

Arm 2 (standard systemic therapy + ablative therapy))

Local Ablative therapy to all sites of disease (including untreated prostate primary)

+ Standard systemic therapy

Group Type: EXPERIMENTAL

Ablative Radiation Therapy

Intervention Type: RADIATION

Undergo stereotactic radiotherapy and/or surgery to all sites of disease (oligometastases and primary prostate if previously untreated).

Standard of care

Intervention Type: OTHER

Patients continue to receive their current planned systemic therapy at the discretion of the treating physician

Interventions

Ablative Radiation Therapy

Undergo stereotactic radiotherapy and/or surgery to all sites of disease (oligometastases and primary prostate if previously untreated).

Intervention Type: RADIATION

Standard of care

Patients continue to receive their current planned systemic therapy at the discretion of the treating physician

Intervention Type: OTHER

Other Intervention Names

SBRT; Stereotactic External Beam Irradiation; Stereotactic Radiation Therapy; Stereotactic Radiotherapy

Eligibility Criteria

Inclusion Criteria

• Histologic diagnosis/confirmation of prostate adenocarcinoma and no evidence of small cell cancer.
• Stage IV at presentation or relapse after curative intent therapy, classification per AJCC 8th edition: M1 disease with ≤ 5 metastases
• ≤ 3 metastases in any non-bone organ system
• Zoladex must commence within 12 weeks prior to randomization or within 12 weeks after randomization.
• Radiology (CT/MRI chest/abdomen/pelvis) within 42 days of randomization
• Bone scan within 42 days of randomization
• All tumours (Primary prostate and metastases) must be amenable to local ablative therapy (radiation and/or surgery).
• Age ≥ 18
• ECOG performance 0-2
• Patient is able (i.e. sufficiently fluent) and willing to complete the quality of life and economics questionnaires in either English or French
• Patient consent must be appropriately obtained in accordance with applicable local and regulatory requirements. Each patient must sign a consent form prior to enrollment in the trial to document their willingness to participate
• Patients must be medically suitable for study treatments as assessed by the appropriate specialties: medical, radiation, and surgical
• Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen
• Patients must be accessible for treatment and follow-up. Investigators must assure themselves the patients randomized on this trial will be available for complete documentation of the treatment, adverse events, and follow-up
• In accordance with CCTG policy, ablative therapy to metastases is to begin within 6 weeks after patient randomization
• Men of childbearing potential must have agreed to use a highly effective contraceptive method to prevent pregnancy while on study
• Patient must consent to provision of, and Investigator must confirm location of and commit to obtain a representative formalin fixed paraffin block of tumour tissue in order that the specific correlative studies described in the protocol may be conducted. Where tissue exists but local centre regulations prohibit submission of blocks of tumour tissue, the approval of the CCTG must be sought prior to randomization of the first patient to allow cores (two 2 mm cores of tumour from the block) and slides (20 x 5 micron thick unstained slides) of representative tumour tissue to be substituted
• Patient must consent to provision of samples of whole blood (for cfDNA) in order that the specific correlative studies described in the protocol may be conducted.

Exclusion Criteria

• Prior treatment with ADT in the neoadjuvant or adjuvant setting, unless treatment was discontinued ≥ 12 months prior to randomization AND total duration of treatment was ≤ 36 months (including expiry of last depot injection).
• Previously diagnosed recurrent/metastatic disease which has been already treated with any systemic therapy or radiotherapy with palliative intent.
• Castration resistant prostate cancer, defined as rising PSA (per PCWG3) or radiographic progression in the setting of castrate levels of serum testosterone (< 1.7 nmol/L).
• Patients who present with de novo stage IV disease with pelvic lymphadenopathy as their only site of metastases (N1 M0), where the primary prostate has never been treated with curative intent prostate surgery or radiotherapy in the past.
• Inability to treat all sites of disease with local ablative therapy
• Patients with parenchymal brain metastases

• Minimum Eligible Age: 18 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Canadian Cancer Society (CCS)

OTHER

Sponsor Role: collaborator

Canadian Cancer Trials Group

NETWORK

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Patrick CF Cheung

Role: STUDY_CHAIR

Odette Cancer Centre, Sunnybrook Health Science Centre, Toronto, ON Canada

M. Tamim Niazi

Role: STUDY_CHAIR

The Jewish General Hospital, Montreal, QC Canada

Locations

BCCA - Victoria

Victoria, British Columbia, Canada

CancerCare Manitoba

Winnipeg, Manitoba, Canada

QEII Health Sciences Centre

Halifax, Nova Scotia, Canada

Royal Victoria Regional Health Centre

Barrie, Ontario, Canada

Health Sciences North

Greater Sudbury, Ontario, Canada

Juravinski Cancer Centre at Hamilton Health Sciences

Hamilton, Ontario, Canada

Kingston Health Sciences Centre

Kingston, Ontario, Canada

Trillium Health Partners - Credit Valley Hospital

Mississauga, Ontario, Canada

Ottawa Hospital Research Institute

Ottawa, Ontario, Canada

Algoma District Cancer Program

Sault Ste. Marie, Ontario, Canada

Odette Cancer Centre

Toronto, Ontario, Canada

University Health Network

Toronto, Ontario, Canada

CIUSSS de l'Est-de-I'lle-de-Montreal

Montreal, Quebec, Canada

CHUM-Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, Canada

The Jewish General Hospital

Montreal, Quebec, Canada

Hotel-Dieu de Quebec

Québec, Quebec, Canada

Allan Blair Cancer Centre

Regina, Saskatchewan, Canada

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, Canada

Countries

Canada

Other Identifiers

PR20

Identifier Type: -

Identifier Source: org_study_id