The Comparison Between the Biomarkers in Inflammatory Bowel Disease Patients and General Control Group

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-08-01

Study Completion Date

2020-12-30

Brief Summary

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The aims of this study is to investigate a blood-based biomarker that can replace endoscopy in patients with inflammatory bowel disease. For this purpose, blood sample of patients wiht inflammatory bowel disease (ulcerative colitis, Crohn 's disease) was collected at the same time the endoscopy is performed, stored after centrifugation, and analyzed accordingly. Selected biomarkers from the blood sample were investigated to compare those of patients with inflammatory bowel disease and those of general controls. Males and females over the age of 19 participated in the study and are excluded if they have chronic kidney disease or blood clotting disease. The outcome is a find of a blood-based biomarker that best reflects a disease activity.

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Detailed Description

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Inflammatory bowel disease refers to chronic inflammation of the unknown origin that occurs in the intestine. It usually refers to ulcerative colitis and Crohn's disease, which are idiopathic inflammatory bowel diseases. While it had been known to be a common disease in the western world, in recent decades the incidence of ulcerative colitis and Crohn's disease has rapidly increased in Korea as well. Endoscopic examination is a gold standard in order to determine the activity of inflammatory bowel disease, but it is hardly performed due to the cost and time of a test. Therefore, it is necessary to find a blood-based biomarker that replaces endoscopy. The objective of the study is to identify a new inflammatory marker that replaces endoscopy by comparing blood samples of patients with inflammatory bowel disease with those of general controls.

Conditions

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Inflammatory Bowel Diseases Irritable Bowel Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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inflammatory bowel disease

inflammatory bowel disease such as Ulcerative colitis and Crohn's disease

inflammatory bowel disease

Intervention Type OTHER

blood based biomarkers in IBD such as REG3 alpha, serum calprotectin and hs-CRP

IBS or Normal Control

Intervention Type OTHER

blood based biomarker compared normal control with IBD

IBS or Normal Control

irritable bowel syndrome patients normal patients

inflammatory bowel disease

Intervention Type OTHER

blood based biomarkers in IBD such as REG3 alpha, serum calprotectin and hs-CRP

IBS or Normal Control

Intervention Type OTHER

blood based biomarker compared normal control with IBD

Interventions

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inflammatory bowel disease

blood based biomarkers in IBD such as REG3 alpha, serum calprotectin and hs-CRP

Intervention Type OTHER

IBS or Normal Control

blood based biomarker compared normal control with IBD

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* people who receive colonoscopy
* people who sign the consent
* having inflammatory bowel disease (ulcerative colitis, Crohn's Dz.) and irritable bowel syndrome

Exclusion Criteria

* those aged over 75 years
* the disabled
* pregnant women
* chronic renal diseases (CLcr \<50ml/min)
* blood coagulopathy (PT INR \> 1.5, aPTT \> 45 seconds, or platelet count \< 50,000/mm)
* people who refuse to sign the consent

Minimum Eligible Age

19 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes