Evaluation of Ocular Lens Proteins in Cataract From Individuals With Down Syndrome

NCT ID: NCT03778528

Last Updated: 2020-07-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

1 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-05-30

Study Completion Date

2020-07-01

Brief Summary

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This study involves the collection ocular lens tissue from individuals with Down syndrome and age-matched controls at the time of cataract surgery.

Detailed Description

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Individuals with Down syndrome have an increased rate of cataract. The reason for this increase is unclear. Normally, once cataracts become a significant impairment, an ophthalmologist will determine when cataract surgery should be performed. When this surgery is performed, cataractous tissues are cut out and discarded with medical waste. In this study, these tissue will be collected and protein analysis performed to determine what changes in different proteins are found in Down syndrome lenses as compared to normal cataractous lenses.

Conditions

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Cataract Down Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Down syndrome

Individuals with Down syndrome undergoing cataract surgery.

cataract surgery

Intervention Type PROCEDURE

tissue collection.

Control

Age-matched controls undergoing cataract surgery.

cataract surgery

Intervention Type PROCEDURE

tissue collection.

Interventions

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cataract surgery

tissue collection.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Undergoing cataract surgery for lens extraction.

Exclusion Criteria

* Known genetic cause other than Down syndrome causing cataract.
Minimum Eligible Age

1 Month

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Children's Hospital Colorado

OTHER

Sponsor Role collaborator

University of Colorado, Denver

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Children's Hospital of Colorado

Aurora, Colorado, United States

Site Status

Countries

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United States

Other Identifiers

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17-0372

Identifier Type: -

Identifier Source: org_study_id

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