LEMTRADA Pregnancy Registry in Multiple Sclerosis

NCT ID: NCT03774914

Last Updated: 2022-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Total Enrollment

42 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-09-01

Study Completion Date

2021-11-22

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Primary Objective:

The primary goal of this registry is to assess the risk of spontaneous abortion in prospective enrolled women exposed to LEMTRADA for multiple sclerosis.

Secondary Objective:

The secondary goals of this registry is to assess maternal, fetal and infant outcome in women with multiple sclerosis, exposed to LEMTRADA.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

From enrollment during pregnancy up to 1 year after delivery for infant follow-up (maximum approximatively 20 months)

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Multiple Sclerosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Lemtrada

Pregnant women exposed to LEMTRADA which is administered by IV infusion for 5 consecutive days, then for 3 consecutive days, 12 months after the first/previous treatment course

Alemtuzumab (GZ402673)

Intervention Type DRUG

Pharmaceutical form:Concentrate for solution for infusion Route of administration: Intravenous infusion

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Alemtuzumab (GZ402673)

Pharmaceutical form:Concentrate for solution for infusion Route of administration: Intravenous infusion

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Lemtrada

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Women with Multiple Sclerosis who were or became pregnant within the period of time between the first infusion of a course of treatment with LEMTRADA to 4 months after their last infusion for that course.
* Women able and willing to provide informed consent for study participation and the requirement of the study. Informed consent will be obtained at the time of enrollment in accordance with local regulatory requirements.

Exclusion Criteria

\- Previous enrollment in this study for a previous pregnancy.

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Genzyme, a Sanofi Company

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Clinical Sciences & Operations

Role: STUDY_DIRECTOR

Sanofi

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Investigational Site Number :840999

New York, New York, United States

Site Status

Investigational Site Number :036001

Box Hill, Victoria, Australia

Site Status

Investigational Site Number :040-001

Linz, , Austria

Site Status

Investigational Site Number :56

Charleroi, , Belgium

Site Status

Investigational Site Number :124999

Canada, , Canada

Site Status

Investigational Site Number :208001

Aarhus C, , Denmark

Site Status

Investigational Site Number :276001

Bochum, , Germany

Site Status

Investigational Site Number :380001

Gallarate (VA), , Italy

Site Status

Investigational Site Number :528999

Netherlands, , Netherlands

Site Status

Investigational Site Number :724999

Spain, , Spain

Site Status

Investigational Site Number :752001

Gothenburg, , Sweden

Site Status

Investigational Site Number :756001

Zurich, , Switzerland

Site Status

Investigational Site Number :826-001

Salford, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Australia Austria Belgium Canada Denmark Germany Italy Netherlands Spain Sweden Switzerland United Kingdom

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

EU PAS - cat 3

Identifier Type: -

Identifier Source: secondary_id

OBS13436

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Rebif® Pregnancy Registry
NCT00338741 COMPLETED