Estimation of Level of ERAP1 Expression in Lesional and Non Lesional Skin of Psoraitic Patients and Healthy Controls.
NCT ID: NCT03767114
Last Updated: 2018-12-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
55 participants
INTERVENTIONAL
2017-01-31
2018-12-31
Brief Summary
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Skin biopsy from patients (psoriasis lesional and non lesional) \& control will be kept in lysis solution (which contains RNAase inhibitor) for the stability of the parameter to be assessed. ERAP-1 gene expression will Research Template 5 Final Version: 8/3/2 016 be detected by quantitative real time -PCR, which include RNA extraction, cDNA synthesis \& PCR.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
DIAGNOSTIC
DOUBLE
Study Groups
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cases of psoriasis
group of 25 cases of psoriasis subjected to skin biopsy for detection of lesional and non lesional expression of ERAP1 by RT-PCR
RT-PCR for ERAP1 detection
Reverse transcriptase -Polymerase Chain Reaction for ERAP1 detection
normal controls
group of 30 age and sex matched healthy controls o subjected to skin biopsy from normal skin for detection of expression of ERAP1 by RT-PCR
RT-PCR for ERAP1 detection
Reverse transcriptase -Polymerase Chain Reaction for ERAP1 detection
Interventions
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RT-PCR for ERAP1 detection
Reverse transcriptase -Polymerase Chain Reaction for ERAP1 detection
Eligibility Criteria
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Inclusion Criteria
* patients over 18 years of age
* both sexes
Exclusion Criteria
* assoiciated autoimmune diseases eg SLE
* pregnancy
18 Years
75 Years
ALL
Yes
Sponsors
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Kasr El Aini Hospital
OTHER
Responsible Party
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Rana F Hilal, MD
Lecturer of dermatology
Other Identifiers
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EgyERAP
Identifier Type: -
Identifier Source: org_study_id
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