Evaluation of Salivary Level of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid

NCT ID: NCT03871114

Last Updated: 2019-07-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-10

Study Completion Date

2019-04-25

Brief Summary

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Thirty patients will be recruited from the outpatient clinic of the faculty of dentistry.fifteen systemically healthy individuals with normal mucosa and fifteen atrophic/erosive oral lichen planus patients. Oral lichen planus patients will be treated with a topical steroid and miR-155 and IL-10 will be assessed in saliva before and after 4 weeks of topical steroids use

Detailed Description

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Conditions

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Oral Lichen Planus

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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OLP patients

fifteen patients with atrophic /erosive OLP will receive treatment with topical triamcinolone acetonide in orabase 1mg/g 3 times /day and assessed every week for 4 weeks

Triamcinolone Acetonide in orabase

Intervention Type DRUG

treatment of OLP with topical steroid

Control group

No interventions assigned to this group

Interventions

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Triamcinolone Acetonide in orabase

treatment of OLP with topical steroid

Intervention Type DRUG

Other Intervention Names

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topical corticosteroid

Eligibility Criteria

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Inclusion Criteria

* Patients clinically and histopathologically diagnosed as having atrophic/erosive OLP.
* Patients free from any other oral lesions
* cooperative patients who agrees to take the supplied medications.
* Patients who are systemically healthy

Exclusion Criteria

* Patients suffering from any systemic disease.
* Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks.
* Treatment with any oral topical medications for at least four weeks prior to the study.
* Pregnant and lactating women.
Minimum Eligible Age

30 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Eman Mohamed Amr

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculty of Dentistry

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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miR-155 OLP

Identifier Type: -

Identifier Source: org_study_id

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