Inflammatory Mediators Associated With Infection by Respiratory Syncytial Virus

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

31 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-04-01

Study Completion Date

2022-04-01

Brief Summary

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Infection with human respiratory syncytial (RS) virus is the most common cause of hospital stay due to pediatric lower respiratory tract infection. An exaggerated immune response contributes to the pathogenesis and small children may have over reactive airways for a long time after an infection.

New research has shown that polymorphonuclear leukocytes (PMNs) are stimulated by the virus. Besides fighting the infection they also cause collateral damage to the host. Among other mechanisms PMNs stimulates mucus formation that affects breathing. They also secrete enzymes, toxic proteins and free radicals that may cause harm to lung tissue and airways.

The current project strives towards identifying and quantifying inflammatory mediators in sputum, urine and blood of children with severe RS-virus infection. The ultimate aim of the project is to, in detail, describe proteins contributing to the pathogenesis of the disease.

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Detailed Description

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Conditions

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Respiratory Tract Infections Respiratory Syncytial Virus Infections

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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RS-virus infection with mechanical ventilation

Patients admitted to the pediatric ICU with verified or suspected RS-virus infection that are mechanically ventilated.

RS-virus infection

Intervention Type OTHER

The intervention consists of lower respiratory tract infection due to RS-virus

Non-RS-virus infection with mechanical ventilation

Patients admitted to the pediatric ICU due to a cause other than a verified or suspected respiratory tract infection.

RS-virus infection

Intervention Type OTHER

The intervention consists of lower respiratory tract infection due to RS-virus

Interventions

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RS-virus infection

The intervention consists of lower respiratory tract infection due to RS-virus

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Admission to pediatric intensive care unit
* Clinical need for invasive ventilation
* Clinical need for intravascular catheterization
* Clinical need for urine bladder catheterization
* Patients with verified or suspected RS-virus-infection or no respiratory tract infection (control group)