A Study to Characterize the Clinical Course of Pregnant Women and Children at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn

NCT ID: NCT03755128

Last Updated: 2025-09-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

17 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-16

Study Completion Date

2023-09-22

Brief Summary

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The primary purpose of the study is to characterize the current standard of care, clinical course, and outcomes of pregnant women and their offspring at high risk for early onset severe hemolytic disease of the fetus and newborn (EOS-HDFN).

Detailed Description

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The outcomes of interest will be assessed from the information collected on the standard of care treatment for EOS-HDFN in pregnant women and their offspring from current pregnancy.

Conditions

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Early Onset Severe Hemolytic Disease of the Fetus and Newborn (EOS-HDFN) Erythroblastosis, Fetal

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Pregnant women and their offspring from current pregnancy

No intervention

Intervention Type OTHER

No investigational drugs will be administered as part of the study

Interventions

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No intervention

No investigational drugs will be administered as part of the study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Pregnant female participants must be ≥18 years of age with an estimated Gestational Age of ≥ 8 weeks; not currently pregnant with multiples (twins or more); and no other clinically relevant abnormalities currently or in their history that the Investigator would deem them ineligible to participate.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Janssen Research & Development, LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Janssen Research & Development, LLC Clinical Trial

Role: STUDY_DIRECTOR

Janssen Research & Development, LLC

Locations

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Columbia University Medical Center

New York, New York, United States

Site Status

University of Cincinnati

Cincinnati, Ohio, United States

Site Status

Oregon Health and Science University

Portland, Oregon, United States

Site Status

UPMC

Pittsburgh, Pennsylvania, United States

Site Status

University of Utah

Salt Lake City, Utah, United States

Site Status

Liverpool Hospital

Liverpool, , Australia

Site Status

The Royal Women's Hospital

Parkville, , Australia

Site Status

Universitair Ziekenhuis Leuven

Leuven, , Belgium

Site Status

The University of British Columbia

Vancouver, British Columbia, Canada

Site Status

Mount Sinai Hospital

Toronto, Ontario, Canada

Site Status

Centre Hospitalier Sainte Justine

Montreal, Quebec, Canada

Site Status

Justus-Liebig-Universität Gießen, Kinderherzzentrum

Giessen, , Germany

Site Status

Leiden University Medical Center

Leiden, , Netherlands

Site Status

Hosp Clinic de Barcelona

Barcelona, , Spain

Site Status

Hosp. Univ. San Cecilio

Granada, , Spain

Site Status

Karolinska Universitetssjukhuset Huddinge

Stockholm, , Sweden

Site Status

Queen Elizabeth Hospital

Edgbaston, , United Kingdom

Site Status

University College London Hospitals NHSFT

London, , United Kingdom

Site Status

Countries

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United States Australia Belgium Canada Germany Netherlands Spain Sweden United Kingdom

Other Identifiers

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MOM-M281-103

Identifier Type: OTHER

Identifier Source: secondary_id

CR109067

Identifier Type: -

Identifier Source: org_study_id

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