Extensive Circumferential Partial Thickness Sclerectomy in Nanophthalmic Eyes

NCT ID: NCT03748732

Last Updated: 2018-11-21

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2011-01-01
• Study Completion Date: 2020-01-01

Brief Summary

Purpose: To describe an extensive scleral excision technique to treat or prevent uveal effusion in nanophthalmic eyes.

Design: Prospective interventional case series.

Methods:

• Setting: Institutional.
• Patient Population: Consecutive patients with nanophthalmos were operated on by one surgeon.
• Intervention Procedure: A single, 90% thickness scleral window extending from immediately behind the extraocular muscle insertions to the vortex veins was performed for 3 and 1/4 quadrants as a circumferential strip.
• Main Outcome Measure: Resolution or prevention of uveal effusion.

Detailed Description

Surgical Technique All surgeries were performed under general anesthesia by one surgeon (AMM). Because the majority of the patients were young with narrow palpebral fissures and very deep set globes in small orbits, special surgical techniques were required. Lateral canthotomy was performed on all patients except for the first. Limbal 360o conjunctival peritomy was followed by securing of each rectus muscles with a modified muscle hook and 2-0 silk suture. Scleral dissection was performed from immediately behind to the muscle insertions posterior to the vortex veins. A 90% depth scleral window was excised over 3 and ¼ quadrants, excluding 3/4 of the superior temporal quadrant to avoid damaging the superior oblique muscle.

Conditions

Nanophthalmos

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Interventions

sclerectomy

scleral flap

Intervention Type: PROCEDURE

Other Intervention Names

maximal scleral excision

Eligibility Criteria

Exclusion Criteria

-

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Rafic Hariri University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Ahmad Mansour, MD, Clinical Professor, AUB

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ahmad Mansour, MD

Role: STUDY_CHAIR

Rafic Hariri University Hospital

Locations

Rafic Hariri University Hospital

Beirut, South Beirut, Lebanon

Countries

Lebanon

References

Carricondo PC, Andrade T, Prasov L, Ayres BM, Moroi SE. Nanophthalmos: A Review of the Clinical Spectrum and Genetics. J Ophthalmol. 2018 May 9;2018:2735465. doi: 10.1155/2018/2735465. eCollection 2018.

Reference Type: RESULT

PMID: 29862063 (View on PubMed)

Mansour A, Stewart MW, Shields CL, Hamam R, Abdul Fattah M, Sheheitli H, Mehanna CJ, Yassine S, Chahine H, Keaik M, Maalouf F, Jaroudi M. Extensive circumferential partial-thickness sclerectomy in eyes with extreme nanophthalmos and spontaneous uveal effusion. Br J Ophthalmol. 2019 Dec;103(12):1862-1867. doi: 10.1136/bjophthalmol-2018-313702. Epub 2019 Mar 15.

Reference Type: DERIVED

PMID: 30877130 (View on PubMed)

Other Identifiers

RaficHaririUHAMM

Identifier Type: -

Identifier Source: org_study_id