A Clinical Trial of A Quadrivalent Influenza Vaccine

NCT ID: NCT03744104

Last Updated: 2024-01-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

2688 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-11

Study Completion Date

2019-10-08

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study is to assess the immunogenicity and safety of a quadrivalent influenza vaccine compared with a trivalent influenza vaccine in participants aged above 3 years.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Influenza

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Quadrivalent influenza vaccine

Quadrivalent influenza vaccine(containing 2 subtypes of B lineage)

Group Type EXPERIMENTAL

Quadrivalent influenza vaccine

Intervention Type BIOLOGICAL

0.5 mL, intramuscular, one dose

Trivalent influenza vaccine A

Trivalent influenza vaccine (containing B/Victoria lineage)

Group Type ACTIVE_COMPARATOR

Trivalent influenza vaccine A

Intervention Type BIOLOGICAL

0.5 mL, intramuscular, one dose

Trivalent influenza vaccine B

Trivalent influenza vaccine (containing B/Yamagata lineage)

Group Type ACTIVE_COMPARATOR

Trivalent influenza vaccine B

Intervention Type BIOLOGICAL

0.5 mL, intramuscular, one dose

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Quadrivalent influenza vaccine

0.5 mL, intramuscular, one dose

Intervention Type BIOLOGICAL

Trivalent influenza vaccine A

0.5 mL, intramuscular, one dose

Intervention Type BIOLOGICAL

Trivalent influenza vaccine B

0.5 mL, intramuscular, one dose

Intervention Type BIOLOGICAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Over the age of three years,healthy population
* Subjects/ (and the guardian) informed consent, voluntarily participated and signed the informed consent form, with the ability to use thermometers, scales and to fill in diary cards as required
* To comply with the requirements of clinical trial program
* Temperature≤37.0℃ on day of enrollment

Exclusion Criteria

* A history of influenza virus infection or suspected infection Abnormal blood routine, blood biochemistry and urine routine examination indexes in last three months
* Any prior administration of influenza vaccine in last six months
* Allergy to any component in the vaccine, especially for egg allergy
* Allergy history of any previous vaccination or drug
* Acute episodes of chronic illness or acute illness on the day of vaccination
* Received a live vaccine within fourteen days prior to receiving the vaccine, or received a subunit or inactivated vaccine within seven days
* Congenital or acquired immune deficiencies, or treatment with immunosuppressive agents, such as long-term treatment with systemic corticosteroids
* Suffering from severe chronic diseases (such as Down's syndrome, diabetes, sicklemia or neurological disorders, Green's Barre syndrome)
* Asthma, required urgent treatment in last two years
* The blood products were received prior to the acceptance of the vaccine
* Known or suspected of respiratory disease, acute infection or chronic disease active period, HIV infection, cardiovascular disease, severe hypertension, malignant tumor during treatment, skin diseases
* History of epilepsy, convulsions, or a family history of psychosis
* Abnormal coagulation function (such as coagulation factor deficiency, coagulation disorders, platelet abnormalities), or obvious bruising or coagulopathy
* Plan to move or leave the area for an extended period of time before the end of the study
* Under anti-tb treatment
* Any prior administration of other research medicine/vaccine in last one month
* Women are pregnant or in the near future planned pregnancy or pregnancy test positive
Minimum Eligible Age

3 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Shanghai Institute Of Biological Products

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Hu Yuemei, PhD

Role: PRINCIPAL_INVESTIGATOR

Jiangsu Province Centers for Disease Control and Prevention

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Suining County Center for Disease Control and Prevention

Xuzhou, Jiangsu, China

Site Status

Xinyi County Center for Disease Control and Prevention

Xuzhou, Jiangsu, China

Site Status

Countries

Review the countries where the study has at least one active or historical site.

China

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

JSVCT060

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Clinical Trials of Quadrivalent Influenza Vaccine
NCT06824519 RECRUITING PHASE1/PHASE2