Identification of Allergen-reactive Antibodies in the Blood of Pollen Allergic Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-01

Study Completion Date

2025-12-31

Brief Summary

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The project examines the hypothesis that monoclonal allergen-neutralizing antibodies can be recombinantly produced from B lymphocytes isolated from pollen allergic patients. Patient samples suitable for antibody cloning are selected based on seroprofiling for the respective allergens. The study aims at isolating lymphocytes from patients with potential allergen-neutralizing IgG in serum and to clone antibodies from antibody gene sequences obtained from B cells of those patients.

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Detailed Description

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Conditions

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Pollen Allergy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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blood withdrawal

Blood withdrawal

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* History of allergic rhinitis, conjunctivitis or asthma due to sensitization to grass- or birch Allergens
* Male or female patients older than 18 years
* Written informed consent for providing blood and also to allow experimental manipulation

Exclusion Criteria

* Age \< 18 years
* Any corticosteroids within the last three days
* Oral corticosteroid therapy within the last ten days
* Parenteral depot corticosteroids within the last three months

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes