Nocturnal Cyclic Enteral Nutrition Infusion Versus Continuous Infusion of Enteral Nutrition

NCT ID: NCT03727165

Last Updated: 2024-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2018-12-11

Study Completion Date

2024-03-12

Brief Summary

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Enteral nutrition is considered the best way to feed those who can´t be fed orally. the standard protocol of administration includes continuous infusion for 24 hours; nonetheless this support is constantly suspended which causes a decrease in the nutrition administered vs the one formulated.

Therefore this randomized clinical trial attempts to compare de standard administration vs. cyclic infusion during night hours measuring the formulated vs the administered volume of enteral nutrition given to the patient.

The control group will be assigned standard 24 hour infusion of enteral nutrition while the experimental group will be assigned cyclic infusion during night hours. The variables include volume formulated, volume given in 24 hours, hours and reasons why the enteral nutrition was suspended, and related complications (abdominal distension, vomiting, and diarrhea).

Detailed Description

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The trial will be carried at San Ignacio University Hospital intensive care unit. Patients included will be over 18 years old who require enteral nutrition according to their attending or to the nutritional and metabolic support team.

260 envelopes with the specific intervention were created. 130 of them are identified with number 0 which corresponds to no intervention, meaning continuous enteral nutrition infusion during 24 hours. The other 130 are assigned with the number 1 which corresponds to intervention, meaning nocturnal cyclic nocturnal enteral nutrition infusion.

Envelopes will be randomly assigned sequentially from number 1 to 260, in which envelope number 1 will be assigned for the first patient. Each patient´s envelope will be labeled with its name and identification number. According to the information contained in the envelope the specific scheme assigned will be formulated.

Envelopes will be kept at the Nutritional and metabolic support´s office; only research assistant will have access to this information.

After 50% of the sample be achieved, there will be a data analysis to review the rate of intolerance to enteral nutrition in both groups.

Principal investigators will review the entire data after completion of the clinical trial, measuring percentage of enteral nutrition delivered and intolerance to enteral nutrition feeding.

Conditions

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Critical Illness Enteral Feeding Intolerance Nutrition Support

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized clinical trial
Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors
Participants will be in the intensive care unit under sedative treatment and will not know about randomization Nurses in the intensive care unit (care providers of enteral nutrition infusion) will not know about the study Outcomes evaluation will be made by one independent clinical epidemiologist

Study Groups

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Continuous infusion

Patients with continuous infusion enteral nutrition in the intensive care unit at San Ignacio University Hospital

Group Type ACTIVE_COMPARATOR

Continuous enteral nutrition infusion

Intervention Type OTHER

Enteral nutrition administration in continuous infusion during 24 hours per day

Cyclic infusion

Patients formulated with cyclic enteral nutrition infusion, administrated at night hours, from 4pm until 7am.

Group Type EXPERIMENTAL

Cyclic enteral nutrition infusion

Intervention Type OTHER

Enteral nutrition administration in continuous infusion during 16 hours per day

Interventions

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Continuous enteral nutrition infusion

Enteral nutrition administration in continuous infusion during 24 hours per day

Intervention Type OTHER

Cyclic enteral nutrition infusion

Enteral nutrition administration in continuous infusion during 16 hours per day

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients over 18 years old, hospitalized in San Ignacio University Hospital intensive care unit.
* Patients with indication on enteral nutrition defined by its attending or by the Nutritional and Metabolic support team.

Exclusion Criteria

-If patient or legal advocate denies to sign consent to participate in this study.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Universitario San Ignacio

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Saul J Rugeles, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital Universitario San Ignacio

Locations

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Hospital Universitario San Ignacio

Bogotá, Bogota DC, Colombia

Site Status

Countries

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Colombia

Other Identifiers

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2018/121

Identifier Type: -

Identifier Source: org_study_id

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