Mitochondrial Genetics of Presbycusis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-04-30

Study Completion Date

2023-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The main goal of this study is to identify mitochondrial mutations associated with presbycusis. Patients affected by severe presbycusis and normal hearing controls (according to ISO7029 norm) will be enrolled if satisfying inclusion criteria (aged from 40 to 80 years old) in existing biocollections in the University Hospital of Angers. After DNA extraction, the mitochondrial genome will be sequenced and data in silico analysed.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

PRecisiOn MEdicine to Target Frailty of Endocrine-metabolic Origin

NCT04856683

Frailty

UNKNOWN

Study of the Association Between Presbycusis With the Incidence of Frailty

NCT04360109

Presbycusis Frailty Syndrome Oxidative Stress

UNKNOWN

Auditory Rehabilitation and Cognition in Alzheimer Patients

NCT03002142

Alzheimer's Disease Hearing Loss

COMPLETED NA

Hearing Loss and Genetic Risks for Alzheimer's Disease and Related Dementia

NCT07288463

Hearing Loss, Adult-Onset Dementia

NOT_YET_RECRUITING NA

Comprehensive Geriatric Assessment in the Elderly Subjects (PROMISING)

NCT05822154

Ageing Frailty

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The study will be proposed to patients consulting in the ENT department of the University Hospital of Angers. After clinical examination and audiometry recording, the eligibility criteria will be checked and inclusion in biocollections proposed. Presbycusis affected subjects will be enrolled in "Mitochondrial Disease biocollection" and normal hearing controls in "Healthy Volunteer biocollection". These biocollections have been approved by the board comitee "Centre de Protection des Personnes".

After DNA extraction and mitochondrial sequencing, candidate variants will be selected by in silico analysis. The presence of mitochondrial variants in both groups (presbycusis and control) will be compared in multivariate analysis if needed.

The nuclear DNA may be sequenced in order to complete the previous analysis and look for any candidate variant .

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Presbycusis Age Related Hearing Loss

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

presbycusis affected patients

affected by a more severe age related hearing loss than expected according to the norm ISO 7029

No interventions assigned to this group

controls

not affected by age related hearing loss according to the norm ISO 7029

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* age related hearing loss more severe than the predicted hearing thresholds according to the norm ISO7029, for the presbycusis population;
* normal hearing according to norm ISO7029 for the control population