Imagio Feasibility Multi-Reader, Multi-Case Study

NCT ID: NCT03708393

Last Updated: 2021-08-06

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

155 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-11-13

Study Completion Date

2018-12-09

Brief Summary

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Controlled, blinded, multi-reader, multi-case study

Detailed Description

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The Imagio Feasibility Reader Study-01 Study is intended to evaluate if a subsequent pivotal study can be implemented to test prospective hypotheses for pre-specified effectiveness endpoints with an acceptable sample size. The Feasibility Study will be based on ITD masses from the PIONEER (NCT01943916) Pivotal study to simultaneously reflect the distributions with and without mammograms as well as site CDU BI-RADS scores within benign and malignant masses as strata. The study population will be split into 3 cohorts - Cohort 1, the 120 patient ITD Population used to run the primary/ secondary analyses. Cohort 2, 30 patients used to run exploratory analyses on false negative rate and Cohort 3, 5 patients used to run exploratory analyses on specific mass types

Conditions

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Breast Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SEQUENTIAL

This will be a controlled, blinded, multi-reader, multi-case (MRMC) study using a sequential design. The study will include 5-12 independent readers depending on qualifications and availability.

Imagio (IUS+OA) Training to be completed prior to any reads taking place. Read 1 is immediately followed by Read 2 within the same read session.

Read 1 (Control): Mammogram (if available) + History + IUS (stills and videos provided), IUS Probability of Malignancy (POM) and BI-RADS scored and the data form locked.

Read 2 (Test): Mammogram (if available) + History + IUS (stills and videos provided), and Imagio (IUS+OA) (stills and videos provided). An interim IUS POM and BI-RADS is recorded as well as a combined Imagio (IUS+OA) POM and BIRADS Pre and Post SenoGram on separate data forms.
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Outcome Assessors
Independent Readers blinded to mass diagnosis

Study Groups

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Imagio IUS

Read 1 - Mammo (as available) + Imagio Ultrasound

Group Type ACTIVE_COMPARATOR

Imagio Ultrasound

Intervention Type DEVICE

Imagio ultrasound images to be reviewed as part of the reader study

Mammography

Intervention Type DEVICE

Mammography images as available per standard of care

Imagio (IUS+OA)

Read 2 - Mammo (as available) + (Imagio Ultrasound + OA)

Group Type EXPERIMENTAL

Imagio (IUS+OA)

Intervention Type DEVICE

The Imagio ultrasound and opto-acoustic images to be reviewed as part of the reader study

Mammography

Intervention Type DEVICE

Mammography images as available per standard of care

Interventions

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Imagio (IUS+OA)

The Imagio ultrasound and opto-acoustic images to be reviewed as part of the reader study

Intervention Type DEVICE

Imagio Ultrasound

Imagio ultrasound images to be reviewed as part of the reader study

Intervention Type DEVICE

Mammography

Mammography images as available per standard of care

Intervention Type DEVICE

Other Intervention Names

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Mammo

Eligibility Criteria

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Inclusion Criteria

\- Female subjects participating in the PIONEER-0 Study of the Imagio Breast Imaging System with known clinical status

Exclusion Criteria

\- Female subjects who did not have known clinical status in the PIONEER-0 Study of the Imagio Breast Imaging System with known clinical status
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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American College of Radiology

OTHER

Sponsor Role collaborator

Seno Medical Instruments Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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A. Thomas Stavros, MD

Role: STUDY_DIRECTOR

Seno Medical

Locations

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American College of Radiology

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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Reader-01

Identifier Type: -

Identifier Source: org_study_id

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