Observational Study of Sub-populations From Cologuard Post-Approval Study (2014-01)

NCT ID: NCT03705013

Last Updated: 2020-04-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

51 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-30

Study Completion Date

2019-11-16

Brief Summary

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The primary endpoint is to obtain longitudinal information on four sub-populations from the Cologuard Post-Approval Study.

Detailed Description

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Subjects who consented to enroll in Exact Sciences Protocol 2014-01, that fit one of the following sub-populations, will be asked to participate in the sub-study. Population 1 includes those whose Cologuard T0 result was positive and colonoscopy result was negative. Population 2 includes those whose Cologuard T0 result was positive and subject declined to complete a colonoscopy per protocol. Population 3 includes those whose Cologuard result at T3 was positive and colonoscopy result at T3 was negative. Population 4 includes those whose Cologuard result at T3 was positive and subject declined to complete a colonoscopy per protocol. Subjects that enrolled in the Exact Sciences Protocol 2014-01, who provided written informed consent to participate in this sub-study, will asked to complete the Follow-Up Questionnaire during a phone interview.

Conditions

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Colorectal Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Baseline Cologuard positive and negative colonoscopy

Those whose Cologuard T0 result was positive and colonoscopy result was negative.

Cologuard

Intervention Type OTHER

Observational

Baseline Cologuard positive and no colonoscopy

Those whose Cologuard T0 result was positive and subject declined to complete a colonoscopy per protocol.

Cologuard

Intervention Type OTHER

Observational

3-year follow-up Cologuard positive and negative colonoscopy

Those whose Cologuard result at T3 was positive and colonoscopy result at T3 was negative.

Cologuard

Intervention Type OTHER

Observational

3-year follow-up Cologuard positive and no colonoscopy

Those whose Cologuard result at T3 was positive and subject declined to complete a colonoscopy per protocol.

Cologuard

Intervention Type OTHER

Observational

Interventions

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Cologuard

Observational

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Subject falls into one of the 4 sub-populations
* Willing to provide informed consent

Exclusion Criteria

* Death
* Investigator/sponsor decision
* Subject withdrew consent
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Exact Sciences Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Thomas C Lenzmeier, M.D., P.C.

Glendale, Arizona, United States

Site Status

Central Arizona Medical Associates, PC

Mesa, Arizona, United States

Site Status

Fiel Family and Sports Medicine, PC

Tempe, Arizona, United States

Site Status

Cassidy Medical Group

Carlsbad, California, United States

Site Status

John D. Homan, MD

Newport Beach, California, United States

Site Status

Desert Oasis Healthcare Medical Group

Palm Springs, California, United States

Site Status

Innovative Research of West Florida

Clearwater, Florida, United States

Site Status

Homestead Medical Research

Homestead, Florida, United States

Site Status

Health Awareness Inc., Jupiter

Jupiter, Florida, United States

Site Status

Health Awareness Inc., Port St. Lucie

Port Saint Lucie, Florida, United States

Site Status

The Kaufmann Clinic

Atlanta, Georgia, United States

Site Status

Indiana University, Eskanazi Hospital, Regenstrief Health Center

Indianapolis, Indiana, United States

Site Status

Centennial Medical Group

Elkridge, Maryland, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

Nevada Family Care

Henderson, Nevada, United States

Site Status

University of North Carolina, Chapel Hill

Chapel Hill, North Carolina, United States

Site Status

Family Practice Center of Wooster

Massillon, Ohio, United States

Site Status

Austin Regional Clinic

Austin, Texas, United States

Site Status

PCP for Life

Montgomery, Texas, United States

Site Status

Wasatch Clinical Research

Salt Lake City, Utah, United States

Site Status

Countries

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United States

Other Identifiers

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2018-09

Identifier Type: -

Identifier Source: org_study_id

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