Impact of Beta-3 Agonist on Psychological Distress and Blood Flow of the Bladder in Women With Overactive Bladder Syndrome

NCT ID: NCT03695822

Last Updated: 2019-03-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE4

Study Classification

INTERVENTIONAL

Study Start Date

2018-12-24

Study Completion Date

2019-01-31

Brief Summary

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We will get the impact of mirabegron on psychological distress, urethra and bladder blood flow and c reactive protein.

Detailed Description

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Background/Purpose: Pharmacologic treatments for female overactive bladder syndrome (OAB) include antimuscarinics and beta-agonist. Similar efficacy has been reported between antimuscarinics and beta-agonist. Antimuscarinics has been found to be beneficial for patients with psychological distress. However, the impact of mirabegron on psychological distress in female OAB remains unknown. In addition, some animal studies found that beta-3 agonist can improve arterial blood flow, bladder ischemia and might improve bladder function; however, there is still lack of human study. Besides, c reactive protein was found to be elevated in female OAB. Nonetheless there is no study mentioning about the impact of mirabegron on c reactive protein. Thus, the aim of this study is to elucidate the impact of mirabegron on psychological distress, bladder blood flow and c reactive protein.

Conditions

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Overactive Bladder Syndrome

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Mirabegron

OAB female patients who will receive beta-3 agonist (mirabegron 2 mg) treatment

Group Type EXPERIMENTAL

Mirabegron 25mg

Intervention Type DRUG

The aim of this study is to elucidate the impact of mirabegron on psychological distress, bladder blood flow and c reactive protein.

Interventions

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Mirabegron 25mg

The aim of this study is to elucidate the impact of mirabegron on psychological distress, bladder blood flow and c reactive protein.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* All OAB female patients
* \>20 years

Exclusion Criteria

* Allergy to mirabegron, urinary tract infections
Minimum Eligible Age

20 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Far Eastern Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Sheng-Mou Hsiao

Chief, Department of Obstetrics & Gynecology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Far Eastern Memorial Hospital

Banqiao District, New Taipei, Taiwan

Site Status

Countries

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Taiwan

Other Identifiers

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107009-F

Identifier Type: -

Identifier Source: org_study_id

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