Clinical Study on the Effect of PTH on CYP3A4 Activity

NCT ID: NCT03695107

Last Updated: 2019-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-02

Study Completion Date

2020-09-10

Brief Summary

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Parathyroid hormone (PTH) may play an important role in the down-regulation of CYP3A4 expression induced by Chronic kidney diseases (CKD). In the study of molecular mechanism, the research group found that the expression of CYP3A2 metabolic enzyme in rat liver decreased in the state of CKD.And PTH may down-regulate the expression of CYP3A4 metabolic enzyme by inhibiting the expression of Nuclear factor- Kilobuse (NF-kB) p65 subunit

Detailed Description

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Conditions

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Chronic Kidney Diseases

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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XBDP1-

Nifedipine controlled released tablets

Intervention Type DRUG

lower blood pressure

XBDP2-

Nifedipine controlled released tablets

Intervention Type DRUG

lower blood pressure

Interventions

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Nifedipine controlled released tablets

lower blood pressure

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Chinese male or female subjects with an age of 18 or older were included;
* The clinical physician diagnosed CKD with hypertension;
* The physician decided that nifedipine controlled release tablets should be given.
* Subjects agree to the study protocol, clinical and follow-up time, and sign the informed consent after the approval of the ethics committee;
* Subjects will be able to communicate well with the investigator and will be able to complete the study as required.

Exclusion Criteria

* Patients with CKD requiring dialysis treatment;
* Other clinical reasons that may be considered inappropriate for inclusion by clinicians.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Third Xiangya Hospital of Central South University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Yang GuoPing, doctor

Role: PRINCIPAL_INVESTIGATOR

The Third Xiangya Hospital of Central South University

Locations

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The Third Xiangya Hospital of Central South University , , China,

Changsha, Hunan, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Yang Guoping, doctor

Role: CONTACT

0086 0731 88618326

Facility Contacts

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Yang Guoping, professor, doctor

Role: primary

0086 0731 88618326

Other Identifiers

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XY3-PTH1708A01

Identifier Type: -

Identifier Source: org_study_id

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