CytoQuel: Clinical Documentation on Effects on Chronic Pain, Wellness, and Reduction of Inflammatory Markers

NCT ID: NCT03690609

Last Updated: 2020-02-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-21

Study Completion Date

2018-01-19

Brief Summary

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The purpose for this protocol is to perform an open-label parallel-arm clinical study in healthy subjects to evaluate the efficacy of a nutraceutical product on chronic pain, vascular health, inflammation, and overall wellness.

Detailed Description

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This is an open-label proof-of-concept human clinical study on the effects of consumption of a nutraceutical blend. Data collection will include a core set of data pertaining to chronic pain and inflammatory markers. Additional data collection will include blood pressure, weight, and overall wellness.

An open-label study design will be used to evaluate the effects of consumption of the nutraceutical product CytoQuel. The product is marketed broadly for many types of inflammation-related health issues. The study is of 8 weeks' duration, with evaluation at baseline, 2, and 8 weeks of product consumption. Study participants will be randomized to one of two groups, taking either 3 caps once daily, or two caps twice daily.

At each visit, the following measurements and procedures are performed: Blood pressure and ankle brachial index, questionnaires pertaining to pain and activities of daily living, and a blood draw. The blood is used for testing of cytokines and vascular health related biomarkers.

Conditions

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Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Nutraceutical intervention, 3 capsules daily.

Participants will consume the nutraceutical blend CytoQuel at a dose of 1850 mg, by consuming 3 capsules daily in the morning.

Group Type ACTIVE_COMPARATOR

CytoQuel

Intervention Type DIETARY_SUPPLEMENT

3 capsules daily.

Nutraceutical intervention, 2 capsules twice daily.

Participants will consume the nutraceutical blend CytoQuel at a dose of 1850 mg, by consuming 4 capsules daily: Two in the morning and two later in the day.

Group Type ACTIVE_COMPARATOR

CytoQuel

Intervention Type DIETARY_SUPPLEMENT

2 capsules twice daily.

Interventions

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CytoQuel

3 capsules daily.

Intervention Type DIETARY_SUPPLEMENT

CytoQuel

2 capsules twice daily.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Adult people of either gender;
* Age 30-75 years (inclusive);
* BMI between 20.0 and 34.9 (inclusive);
* Experiencing chronic pain in at least one specific anatomical area for more than 6 months.

Exclusion Criteria

* Active uncontrolled auto-immune disease (for example: rheumatoid arthritis, lupus, inflammatory bowel disease, Celiac disease);
* Known active cardiovascular health issues;
* Cancer during past 12 months;
* Chemotherapy during past 12 months;
* Currently taking blood pressure medication;
* Currently taking blood thinning medication (81mg aspirin allowed);
* Currently taking cholesterol-lowering medication (for example: statins);
* Currently taking Coumadin;
* Currently taking nutritional supplements judged by the study coordinator to negate or camouflage the effects of the test product;
* Currently taking prescription pain medications;
* Getting regular joint injections (such as cortisone shots);
* Major surgery within the past 3 months;
* Major trauma within the past 3 months;
* Any other condition or observation that the investigator judges may adversely affect the person's ability to complete the study;
* Any other significant disease or disorder that the investigator judges may put the subject at risk because of participation in the study, or may influence the result of the study;
* Hypersensitivity or known allergy to green tea or black tea;
* Participation in another research study involving an investigational product in the past month;
* Planned surgery within 2 weeks of completing the study;
* Previous major surgery to stomach or intestines \[(absorption of test product may be altered) minor surgery is not a problem, including appendix and gallbladder removal\];
* Unwilling to maintain a constant intake of supplements over the duration of the study;
* Women who are pregnant, nursing, or trying to become pregnant.
Minimum Eligible Age

30 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Natural Immune Systems Inc

OTHER

Sponsor Role lead

Responsible Party

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Gitte Jensen, Ph.D.

Research director

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gitte Jensen

Role: PRINCIPAL_INVESTIGATOR

NIS Labs

Locations

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NIS Labs

Klamath Falls, Oregon, United States

Site Status

Countries

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United States

Other Identifiers

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NIS143002

Identifier Type: -

Identifier Source: org_study_id

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