Exercise in Improving Health and Quality of Life in Breast Cancer Survivors

NCT ID: NCT03679559

Last Updated: 2023-09-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

83 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-06

Study Completion Date

2022-06-02

Brief Summary

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This randomized pilot trial studies how well exercise works in improving health and quality of life in breast cancer survivors. Participating in an exercise program to maintain physical activity may help to improve health and quality of life in breast cancer survivors.

Detailed Description

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PRIMARY OBJECTIVE:

I. To assess the feasibility of conducting a 12-week preference option randomized exercise intervention program in breast cancer survivors.

SECONDARY OBJECTIVE:

I. To assess the adherence rate of each of the four 12-week intervention programs by breast cancer survivors in a randomized treatment arm and a patient preference arm.

OUTLINE: Participants are randomized into 1 of 5 arms.

ARM I: Participants wear Fitbit, receive home-based DVD containing instructions to warm-up and cool-down, and walk 10000 steps per day over 12 weeks in order to achieve the 150 minutes per week of moderate intensity exercise. Participants also undergo resistance training by watching the illustration video and completing 6 total blocks of 2-week per block exercise using the Thera-BandR exercise bands.

ARM II: Participants wear Fitbit and receive a XBOX system and the video game to strive for at least 3 50-minute medium or high intensity classes per week over 12 weeks. Participants may also take 20-minute classes or a mixture of 50- and 20-minute classes to meet the target. Participants undergo resistance training as in Arm I.

ARM III: Participants wear Fitbit and attend supervised High Intensity Interval Training (HIIT) exercise sessions 3 days per week over 12 weeks. Participants undergo resistance training as in Arm I.

ARM IV: Participants wear Fitbit and attend supervised moderate intensity walking sessions weekly for 50-60 each over 12 weeks. Participants undergo resistance training as in Arm I.

ARM V: Participants wear Fitbit and continue their usual physical activity over 12 weeks.

After completion of study intervention, participants are followed up at 2 weeks and 1 month.

Conditions

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Invasive Breast Carcinoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Arm I (home-based walking program, resistance training)

Participants wear Fitbit, receive home-based DVD containing instructions to warm-up and cool-down, and brisk walk 30 minutes per day 5 days a week in order to achieve the 150 minutes per week of moderate intensity exercise. Participants also receive resistance training by watching the illustration video and completing 6 total blocks of 2-week per block exercise using the Thera-BandR exercise bands.

Group Type EXPERIMENTAL

Exercise Intervention (home walking program and resistance training)

Intervention Type BEHAVIORAL

Complete home-based walking program and resistance training

Exercise Intervention (HIIT program and resistance training)

Intervention Type BEHAVIORAL

Complete HIIT program and resistance training

Informational Intervention

Intervention Type OTHER

Watch video

Laboratory Biomarker Analysis

Intervention Type OTHER

Correlative studies

Monitoring Device

Intervention Type DEVICE

Wear Fitbit

Quality-of-Life Assessment

Intervention Type OTHER

Ancillary studies

Questionnaire Administration

Intervention Type OTHER

Ancillary studies

Arm II (home-based Zumba program, resistance training)

Participants wear Fitbit and receive a XBOX system and the video game to strive for at least 3 50-minute medium or high intensity classes per week over 12 weeks. Participants may also take 20-minute classes or a mixture of 50- and 20-minute classes to meet the target. Participants receive resistance training as in Arm I.

Group Type EXPERIMENTAL

Exercise Intervention (home-based Zumba program and resistance training)

Intervention Type BEHAVIORAL

Complete home-based Zumba program and resistance training

Informational Intervention

Intervention Type OTHER

Watch video

Laboratory Biomarker Analysis

Intervention Type OTHER

Correlative studies

Monitoring Device

Intervention Type DEVICE

Wear Fitbit

Quality-of-Life Assessment

Intervention Type OTHER

Ancillary studies

Questionnaire Administration

Intervention Type OTHER

Ancillary studies

Arm III (HIIT, resistance training)

Participants wear Fitbit and attend supervised HIIT exercise sessions 3 days per week over 12 weeks. Participants receive resistance training as in Arm I.

Group Type EXPERIMENTAL

Exercise Intervention (HIIT program and resistance training)

Intervention Type BEHAVIORAL

Complete HIIT program and resistance training

Informational Intervention

Intervention Type OTHER

Watch video

Monitoring Device

Intervention Type DEVICE

Wear Fitbit

Quality-of-Life Assessment

Intervention Type OTHER

Ancillary studies

Questionnaire Administration

Intervention Type OTHER

Ancillary studies

Arm IV (supervised moderate intensity walking program)

Participants wear Fitbit and attend supervised moderate intensity walking sessions weekly for 50-60 each over 12 weeks. Participants undergo resistance training as in Arm I.

Group Type ACTIVE_COMPARATOR

Exercise Intervention (HIIT program and resistance training)

Intervention Type BEHAVIORAL

Complete HIIT program and resistance training

Arm V (usual physical activity)

Participants wear Fitbit and continue their usual physical activity over 12 weeks.

Group Type ACTIVE_COMPARATOR

Best Practice

Intervention Type OTHER

Continue usual physical activity

Interventions

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Best Practice

Continue usual physical activity

Intervention Type OTHER

Exercise Intervention (home walking program and resistance training)

Complete home-based walking program and resistance training

Intervention Type BEHAVIORAL

Exercise Intervention (home-based Zumba program and resistance training)

Complete home-based Zumba program and resistance training

Intervention Type BEHAVIORAL

Exercise Intervention (HIIT program and resistance training)

Complete HIIT program and resistance training

Intervention Type BEHAVIORAL

Informational Intervention

Watch video

Intervention Type OTHER

Laboratory Biomarker Analysis

Correlative studies

Intervention Type OTHER

Monitoring Device

Wear Fitbit

Intervention Type DEVICE

Quality-of-Life Assessment

Ancillary studies

Intervention Type OTHER

Questionnaire Administration

Ancillary studies

Intervention Type OTHER

Other Intervention Names

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standard of care standard therapy Monitor Quality of Life Assessment

Eligibility Criteria

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Inclusion Criteria

* Understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure
* Have a previous history of invasive breast cancer who have completed treatment except for hormonal therapy and zoledronic acid (Zometa)
* Do not meet the United States (U.S.) Center for Disease Control and Prevention's physical activity guidelines (150 minutes or 2 hours and 30 minutes a week of moderate-intensity exercise)
* Meets criteria for participation in low to moderate risk exercise based on the American College of Sports Medicine guideline (ACSM)

Exclusion Criteria

* Have uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
* Are pregnant or nursing
* Are unwilling or unable to follow protocol requirements
* Have any condition which in the investigator's opinion deems the subject an unsuitable candidate to participate in this study
* Have metastatic breast cancer
* Have orthopedic or neuromuscular disorders or arthritis that preclude participation in exercise
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Roswell Park Cancer Institute

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ellis Levine

Role: PRINCIPAL_INVESTIGATOR

Roswell Park Cancer Institute

Locations

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Roswell Park Cancer Institute

Buffalo, New York, United States

Site Status

Countries

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United States

Other Identifiers

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NCI-2018-00455

Identifier Type: REGISTRY

Identifier Source: secondary_id

I 32816

Identifier Type: OTHER

Identifier Source: secondary_id

I 32816

Identifier Type: -

Identifier Source: org_study_id

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