A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy

NCT ID: NCT03675308

Last Updated: 2025-08-05

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

964 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-25

Study Completion Date

2026-09-28

Brief Summary

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The purpose of this study is to compare the safety and efficacy of risankizumab versus placebo in participants with moderately to severely active psoriatic arthritis (PsA).

Detailed Description

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The study consists of a Screening Period (approximately 35 days), Period 1, Period 2, and a 20-week Follow-up Period. Period 1 is a 24-week randomized, double-blind, placebo-controlled, parallel-group treatment period. Period 2 is the long-term treatment period and starts at Week 24. To maintain the blind to the original treatment allocation, treatment at the Week 24 Visit is blinded: participants randomized to placebo receive blinded risankizumab 150 mg, and participants randomized to risankizumab receive blinded placebo. At Week 28 and for the remaining dosing visits (to Week 316), all participants are to receive open-label risankizumab 150 mg every 12 weeks. Participants will remain blinded to the original randomization allocation for the duration of the study. The total study duration is 336 weeks including a telephone call 140 days (20 weeks) after last dose of study drug.

Conditions

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Psoriatic Arthritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo

Participants randomized to receive double-blind placebo at Week 0, Week 4, and Week 16 in Period 1. At Week 24 participants will receive 150 mg risankizumab followed by open-label 150 mg risankizumab at Week 28, and every 12 weeks thereafter in Period 2 until the final dosing time point at Week 316.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type BIOLOGICAL

Placebo for risankizumab administered by subcutaneous injection

Risankizumab

Intervention Type BIOLOGICAL

Risankizumab administered by subcutaneous injection

Risankizumab

Participants randomized to receive 150 mg risankizumab administered by subcutaneous injection at Week 0, Week 4, and Week 16 in Period 1. At Week 24 participants will receive blinded placebo followed by open-label 150 mg risankizumab at Week 28, and every 12 weeks thereafter in Period 2 until the final dosing time point at Week 316.

Group Type EXPERIMENTAL

Placebo

Intervention Type BIOLOGICAL

Placebo for risankizumab administered by subcutaneous injection

Risankizumab

Intervention Type BIOLOGICAL

Risankizumab administered by subcutaneous injection

Interventions

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Placebo

Placebo for risankizumab administered by subcutaneous injection

Intervention Type BIOLOGICAL

Risankizumab

Risankizumab administered by subcutaneous injection

Intervention Type BIOLOGICAL

Other Intervention Names

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ABBV-066 BI 655066 SKYRIZI

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of PsA with symptom onset at least 6 months prior to the Screening Visit and fulfillment of the Classification Criteria for PsA (CASPAR) at the Screening Visit.
* Participant has active disease at Baseline defined as ≥ 5 tender joints (based on 68 joint counts) and ≥ 5 swollen joints (based on 66 joint counts)
* Diagnosis of active plaque psoriasis with at least one psoriatic plaque of ≥ 2 cm diameter or nail changes consistent with psoriasis at Screening Visit.
* Participant has demonstrated an inadequate response or intolerance to or contraindication for conventional synthetic disease modifying anti-rheumatic drugs (csDMARD) therapy(ies).
* Presence of either at Screening:

* ≥ 1 erosion on radiograph as determined by central imaging review or;
* High sensitivity C-reactive protein (hsCRP) ≥ 3.0 mg/L.

Exclusion Criteria

* Participant is considered by investigator, for any reason, to be an unsuitable candidate for the study.
* Participant has a known hypersensitivity to risankizumab.
* Participant has previous treatment with biologic agent.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

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Pinnacle Research Group /ID# 167955

Anniston, Alabama, United States

Site Status

Sun Valley Arthritis Center Ltd. /ID# 200270

Peoria, Arizona, United States

Site Status

AZ Arthritis and Rheumotology Research, PLLC /ID# 209873

Phoenix, Arizona, United States

Site Status

Arizona Arthritis & Rheumatology Research, PLLC /ID# 209875

Tucson, Arizona, United States

Site Status

Southern Arizona VA Health Care System /ID# 209247

Tucson, Arizona, United States

Site Status

Arthritis and Rheumatism Associates /ID# 209882

Jonesboro, Arkansas, United States

Site Status

Valerius Medical Group & Research Center /ID# 207428

Los Alamitos, California, United States

Site Status

Rheumatology Center of San Diego /ID# 201642

San Diego, California, United States

Site Status

Inland Rheum Clin Trials Inc. /ID# 201641

Upland, California, United States

Site Status

Medvin Clinical Research /ID# 211127

Whittier, California, United States

Site Status

New England Research Associates, LLC /ID# 207237

Bridgeport, Connecticut, United States

Site Status

Danbury Clinical Research, LLC /ID# 209517

Danbury, Connecticut, United States

Site Status

Arthritis & Osteoporosis Center /ID# 207236

Hamden, Connecticut, United States

Site Status

Arthritis & Rheumatic Disease Specialties /ID# 210802

Aventura, Florida, United States

Site Status

Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 211099

Boca Raton, Florida, United States

Site Status

SIMED Health, LLC /ID# 207461

Gainesville, Florida, United States

Site Status

Sweet Hope Research Specialty Inc /ID# 209393

Hialeah, Florida, United States

Site Status

Jacksonville Center for Clinical Research /ID# 209876

Jacksonville, Florida, United States

Site Status

Rheum Assoc of Central FL /ID# 201622

Orlando, Florida, United States

Site Status

HMD Research LLC /ID# 208427

Orlando, Florida, United States

Site Status

IRIS Research and Development, LLC /ID# 208955

Plantation, Florida, United States

Site Status

ForCare Clinical Research /ID# 168034

Tampa, Florida, United States

Site Status

Arthritis and Rheumatology /ID# 168046

Atlanta, Georgia, United States

Site Status

Affinity Clinical Research /ID# 210816

Oak Brook, Illinois, United States

Site Status

OrthoIllinois /ID# 205300

Rockford, Illinois, United States

Site Status

Springfield Clinic /ID# 200244

Springfield, Illinois, United States

Site Status

Klein and Associates MD /ID# 169483

Hagerstown, Maryland, United States

Site Status

The Center for Rheumatology and Bone Research /ID# 168017

Wheaton, Maryland, United States

Site Status

Clinical Pharmacology Study Gr /ID# 168019

Worcester, Massachusetts, United States

Site Status

Advanced Rheumatology, PC /ID# 168042

Lansing, Michigan, United States

Site Status

June DO, PC /ID# 208915

Lansing, Michigan, United States

Site Status

St. Paul Rheumatology /ID# 208471

Eagan, Minnesota, United States

Site Status

Logan Health Research /ID# 213707

Kalispell, Montana, United States

Site Status

Physician Research Collaboration, LLC /ID# 208670

Lincoln, Nebraska, United States

Site Status

Center for Rheumatology LLP /ID# 207313

Albany, New York, United States

Site Status

NYU Langone Ambulatory Care Brooklyn Heights /ID# 207310

Brooklyn, New York, United States

Site Status

Joint & Muscle Research Instit /ID# 208620

Charlotte, North Carolina, United States

Site Status

Medication Management, LLC /ID# 211734

Greensboro, North Carolina, United States

Site Status

Coastal Carolina Health Care /ID# 208619

New Bern, North Carolina, United States

Site Status

Velocity Clinical Research /ID# 200452

Blue Ash, Ohio, United States

Site Status

Marietta Memorial Hospital /ID# 210179

Marietta, Ohio, United States

Site Status

Paramount Medical Research Con /ID# 201583

Middleburg Heights, Ohio, United States

Site Status

STAT Research, Inc. /ID# 213805

Springboro, Ohio, United States

Site Status

Health Research of Oklahoma /ID# 168027

Oklahoma City, Oklahoma, United States

Site Status

Altoona Ctr Clinical Res /ID# 168037

Duncansville, Pennsylvania, United States

Site Status

Allegheny Health Network Research Institute /ID# 210349

Pittsburgh, Pennsylvania, United States

Site Status

Clinical Research Ctr Reading /ID# 168070

Wyomissing, Pennsylvania, United States

Site Status

Nashville Arthritis and Rheumatology /ID# 168069

Nashville, Tennessee, United States

Site Status

Amarillo Ctr for Clin Research /ID# 208347

Amarillo, Texas, United States

Site Status

Precision Comprehensive Clinical Research Solutions /ID# 208386

Colleyville, Texas, United States

Site Status

Dallas VA Medical Center /ID# 208389

Dallas, Texas, United States

Site Status

Precision Comprehensive Clinical Research Solutions /ID# 210597

Fort Worth, Texas, United States

Site Status

Advanced Rheumatology of Houston /ID# 208354

The Woodlands, Texas, United States

Site Status

DM Clinical Research /ID# 208351

Tomball, Texas, United States

Site Status

Kadlec Clinic Rheumatology /ID# 207969

Kennewick, Washington, United States

Site Status

Rheumatology and Pulmonary Clinic /ID# 200446

Beckley, West Virginia, United States

Site Status

Aurora Rheumatology and Immunotherapy Center /ID# 168066

Franklin, Wisconsin, United States

Site Status

Holy Family Memorial, Inc. /ID# 209387

Manitowoc, Wisconsin, United States

Site Status

Gundersen Clinic, Ltd /ID# 209459

Onalaska, Wisconsin, United States

Site Status

Framingham Centro Medico /ID# 210409

La Plata, Buenos Aires, Argentina

Site Status

Hospital General de Agudos J. M. Ramos Mejia /ID# 169164

Buenos Aires, Ciuadad Autonoma de Buenos Aires, Argentina

Site Status

Hospital Italiano de Buenos Aires /ID# 208474

Ciudad Autonoma Buenos Aires, Ciuadad Autonoma de Buenos Aires, Argentina

Site Status

DOM Centro de Reumatologia /ID# 208479

Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma de Buenos Aires, Argentina

Site Status

Fundacion CIDEA /ID# 210494

Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma de Buenos Aires, Argentina

Site Status

Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich /ID# 211622

Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma de Buenos Aires, Argentina

Site Status

Centro de Enfermedades del Hígado y Aparato Digestivo /ID# 169163

Rosario, Santa Fe Province, Argentina

Site Status

Instituto CAICI /ID# 169168

Rosario, Santa Fe Province, Argentina

Site Status

Centro Medico Privado de Reumatologia /ID# 208343

San Miguel de Tucumán, Tucumán Province, Argentina

Site Status

Duplicate_Inst de Rehab Psicofisica /ID# 214681

Buenos Aires, , Argentina

Site Status

Duplicate_Hospital Privado Univesitario /ID# 211623

Córdoba, , Argentina

Site Status

Cimer /Id# 169167

San Miguel de Tucumán, , Argentina

Site Status

The Canberra Hospital /ID# 207592

Garran, Australian Capital Territory, Australia

Site Status

Royal Brisbane and Women's Hospital /ID# 212785

Herston, Queensland, Australia

Site Status

Rheumatology Research Unit Sunshine Coast /ID# 207200

Maroochydore, Queensland, Australia

Site Status

Griffith University /ID# 207505

Southport, Queensland, Australia

Site Status

Flinders Medical Centre /ID# 210562

Bedford Park, South Australia, Australia

Site Status

Emeritus Research /ID# 207202

Camberwell, Victoria, Australia

Site Status

Monash Medical Centre /ID# 208034

Clayton, Victoria, Australia

Site Status

Duplicate_UZ Ghent /ID# 210036

Ghent, Oost-Vlaanderen, Belgium

Site Status

ReumaClinic /ID# 208213

Genk, , Belgium

Site Status

ZNA - Jan Palfijn /ID# 208212

Merksem, , Belgium

Site Status

University Clinical Centre of the Republic of Srpska /ID# 208268

Banja Luka, Republika Srpska, Bosnia and Herzegovina

Site Status

University Clinical Centre of the Republic of Srpska /ID# 208269

Banja Luka, Republika Srpska, Bosnia and Herzegovina

Site Status

University Clinical Centre of the Republic of Srpska /ID# 210047

Banja Luka, Republika Srpska, Bosnia and Herzegovina

Site Status

Clinical Center University of Sarajevo /ID# 208272

Sarajevo, , Bosnia and Herzegovina

Site Status

SER - Serviços Especializados em Reumatologia /ID# 207489

Salvador, Estado de Bahia, Brazil

Site Status

CMiP - Centro Mineiro de Pesquisa Ltda - ME /ID# 207496

Juiz de Fora, Minas Gerais, Brazil

Site Status

EDUMED Educacao em Saude S/S L /ID# 207488

Curitiba, Paraná, Brazil

Site Status

LMK Sevicos Medicos S/S /ID# 207491

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

CPCLIN - Centro de Pesquisas Clínicas /ID# 207493

São Paulo, , Brazil

Site Status

Medical center Medconsult /ID# 211399

Pleven, , Bulgaria

Site Status

Medical center Excelsior /ID# 167741

Sofia, , Bulgaria

Site Status

Diagnostic consultative center 17 Sofia /ID# 210506

Sofia, , Bulgaria

Site Status

Military Medical Academy Multiprofile Hospital /ID# 210829

Sofia, , Bulgaria

Site Status

Percuro Clinical Research, Ltd /ID# 169601

Victoria, British Columbia, Canada

Site Status

Manitoba Clinic /ID# 206819

Winnipeg, Manitoba, Canada

Site Status

CIADS Research Co Ltd /ID# 169600

Winnipeg, Manitoba, Canada

Site Status

SKIN Centre for Dermatology /ID# 169604

Peterborough, Ontario, Canada

Site Status

K. Papp Clinical Research /ID# 169603

Waterloo, Ontario, Canada

Site Status

Groupe de Recherche en Maladies Osseuses Inc /ID# 169598

Sainte-Foy, Quebec, Canada

Site Status

Dr. Latha Naik /ID# 212188

Saskatoon, Saskatchewan, Canada

Site Status

CTR Estudios Clinicos /ID# 208166

Providencia, , Chile

Site Status

Centro Internacional de Estudios Clinicos /ID# 209908

Santiago, , Chile

Site Status

Clinica Dermacross S.A /ID# 208163

Vitacura Santiago, , Chile

Site Status

Poliklinika Repromed /ID# 208628

Zagreb, City of Zagreb, Croatia

Site Status

Poliklinika Solmed /ID# 210965

Zagreb, City of Zagreb, Croatia

Site Status

UHC Osijek /ID# 208623

Osijek, County of Osijek-Baranja, Croatia

Site Status

Klinicki bolnicki centar Rijeka /ID# 208621

Rijeka, Primorje-Gorski Kotar County, Croatia

Site Status

Klinicki bolnicki centar Split /ID# 208626

Split, Split-Dalmatia County, Croatia

Site Status

Medical Center Kuna-Peric /ID# 208047

Zagreb, , Croatia

Site Status

Poliklinika Bonifarm /ID# 208750

Zagreb, , Croatia

Site Status

Revmacentrum MUDr. Mostera, s.r.o. /ID# 209025

Brno, , Czechia

Site Status

PV MEDICAL Services s.r.o. /ID# 210222

Prague, , Czechia

Site Status

MUDr. Zuzana Stejfova - revmatologicka ambulance /ID# 209027

Prague, , Czechia

Site Status

Affidea Praha s.r.o. /ID# 210223

Prague, , Czechia

Site Status

MEDICAL PLUS, s.r.o. /ID# 210439

Uherské Hradiště, , Czechia

Site Status

Bispebjerg and Frederiksberg Hospital /ID# 207576

Frederiksberg, Capital Region, Denmark

Site Status

Aarhus University Hospital /ID# 168761

Aarhus C, Central Jutland, Denmark

Site Status

North Estonia Medical Centre /ID# 208325

Mustamäe, Harju, Estonia

Site Status

Innomedica /ID# 211416

Tallinn, Harju, Estonia

Site Status

MediTrials /ID# 207816

Tartu, Tartu, Estonia

Site Status

Helsinki University Hospital /ID# 207724

Helsinki, Uusimaa, Finland

Site Status

Ite Pihlajanlinna Kuopio /ID# 208322

Kuopio, , Finland

Site Status

Turku University Hospital /ID# 207726

Turku, , Finland

Site Status

Rheumazentrum Ruhrgebiet /ID# 207216

Herne, North Rhine-Westphalia, Germany

Site Status

Immanuel Krankenhaus Berlin /ID# 207218

Buch, , Germany

Site Status

Center of Innovative Diagnostics and Therapeutics (CIRI GmbH) /ID# 209483

Frankfurt, , Germany

Site Status

MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH /ID# 209484

Hamburg, , Germany

Site Status

General Hospital Asklepieio Voulas /ID# 212956

Athens, Attica, Greece

Site Status

University General Hospital of Heraklion PA.G.N.I /ID# 206839

Heraklion, Crete, Greece

Site Status

424 General MILITARY Hospital /ID# 210974

Efkarpia (Thessalonikis), Thessaloniki, Greece

Site Status

Naval Hospital of Athens /ID# 206838

Athens, , Greece

Site Status

Olympion General Clinic SA /ID# 207048

Pátrai, , Greece

Site Status

Sheba Medical Center /ID# 207474

Ramat Gan, Tel Aviv, Israel

Site Status

Barzilai Medical Center /ID# 207476

Ashkelon, , Israel

Site Status

Rambam Health Care Campus /ID# 208170

Haifa, , Israel

Site Status

Meir Medical Center /ID# 207473

Kfar Saba, , Israel

Site Status

Rabin Medical Center /ID# 207475

Petah Tikva, , Israel

Site Status

Duplicate_Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 207799

Modena, Emilia-Romagna, Italy

Site Status

Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona /ID# 207269

Ancona, , Italy

Site Status

A.O.U. Policlinico G. Rodolico S.Marco - Presidio San Marco /ID# 207795

Catania, , Italy

Site Status

Duplicate_Policlinico Univ Tor Vergata /ID# 207271

Rome, , Italy

Site Status

Azienda Ospedaliera Universitaria di Verona/Ospedale Borgo Roma /ID# 207265

Verona, , Italy

Site Status

M & M Centrs LTD /ID# 208733

Ādaži, , Latvia

Site Status

D.Saulites-Kandevicas PP in Cardiology and Rheumatology /ID# 207224

Liepāja, , Latvia

Site Status

Pauls Stradins Clinical University Hospital /ID# 207220

Riga, , Latvia

Site Status

Clinic ORTO /ID# 216218

Riga, , Latvia

Site Status

Riga East Clinical University Hospital /ID# 207223

Riga, , Latvia

Site Status

VAKK Dr. Kilda's Clinic /ID# 207330

Kaunas, , Lithuania

Site Status

Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 207331

Kaunas, , Lithuania

Site Status

Klaipeda University Hospital /ID# 207329

Klaipėda, , Lithuania

Site Status

Republican Siauliai hospital /ID# 207328

Šiauliai, , Lithuania

Site Status

Hospital Tuanku Jaafar /ID# 207919

Seremban, Negeri Sembilan, Malaysia

Site Status

Hospital Raja Permaisuri Bainun /ID# 207920

Ipoh, Perak, Malaysia

Site Status

Hospital Selayang /ID# 208938

Batu Caves, Selangor, Malaysia

Site Status

University Malaya Med Ctr /ID# 208937

Kuala Lumpur, , Malaysia

Site Status

Centro Integral en Reumatologia S.A de C.V /ID# 208346

Guadalajara, Jalisco, Mexico

Site Status

CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 208331

Mexico City, Mexico City, Mexico

Site Status

Eukarya PharmaSite, SC /ID# 208431

Monterrey, Nuevo León, Mexico

Site Status

Centro Peninsular de Investigación Clínica SCP /ID# 208345

Colonia Centro, Yucatán, Mexico

Site Status

Hospital General Regional No. 1 Dr. Carlos Mac Gregor Sánchez Navarro /ID# 210835

Mexico City, , Mexico

Site Status

RM Pharma Specialists S.A de C.V /ID# 208330

Mexico City, , Mexico

Site Status

Antonius Ziekenhuis /ID# 208587

Sneek, Provincie Friesland, Netherlands

Site Status

Universitair Medisch Centrum Groningen /ID# 208580

Groningen, , Netherlands

Site Status

Medisch Centrum Leeuwarden /ID# 168453

Leeuwarden, , Netherlands

Site Status

Middlemore Clinical Trials /ID# 213256

Papatoetoe, Auckland, New Zealand

Site Status

Waikato Hospital /ID# 213257

Hamilton, Waikato Region, New Zealand

Site Status

CGM Research Trust /ID# 210498

Burwood, , New Zealand

Site Status

Spolka Lekarzy INTERCOR /ID# 210191

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Site Status

Nasz Lekarz Przychodnie Medyczne /ID# 216176

Torun, Kuyavian-Pomeranian Voivodeship, Poland

Site Status

Malopolskie Centrum Kliniczne /ID# 208007

Krakow, Lesser Poland Voivodeship, Poland

Site Status

McBk Sc /Id# 209132

Grodzisk Mazowiecki, Masovian Voivodeship, Poland

Site Status

Centrum Medyczne Reuma Park w Warszawie /ID# 210352

Warsaw, Masovian Voivodeship, Poland

Site Status

Osteo-Medic S.C. /ID# 208008

Bialystok, Podlaskie Voivodeship, Poland

Site Status

ClinicMed Daniluk, Nowak Sp.j. /ID# 210824

Bialystok, Podlaskie Voivodeship, Poland

Site Status

Centrum Kliniczno-Badawcze /ID# 208010

Elblag, Warmian-Masurian Voivodeship, Poland

Site Status

ETYKA-Osrodek Badan Klinicznych /ID# 216241

Olsztyn, Warmian-Masurian Voivodeship, Poland

Site Status

Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE /ID# 208145

Vila Nova de Gaia, Porto District, Portugal

Site Status

Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 208147

Ponte de Lima, Viana do Castelo District, Portugal

Site Status

Centro Hospitalar do Baixo Vouga /ID# 215979

Aveiro, , Portugal

Site Status

CCA Braga - Hospital de Braga /ID# 208146

Braga, , Portugal

Site Status

Instituto Português De Reumatologia /ID# 208149

Lisbon, , Portugal

Site Status

Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 208148

Lisbon, , Portugal

Site Status

Mindful Medical Research /ID# 211129

San Juan, , Puerto Rico

Site Status

Cabinet Medical Dr Triff Carina /Id# 207528

Timișoara, Timiș County, Romania

Site Status

Spitalul Clinic Sf. Maria /ID# 210054

Bucharest, , Romania

Site Status

Spitalul Clinic Judetean de Urgenta Cluj -Napoca /ID# 207340

Cluj-Napoca, , Romania

Site Status

Spitalul Clinic de Recuperare Iasi /ID# 207371

Iași, , Romania

Site Status

LLC Family Outpatient Clinic № /ID# 169510

Korolev, Moscow, Russia

Site Status

Research Institute of Rheumatology named after V.A. Nasonova /ID# 207643

Moscow, Moscow, Russia

Site Status

LLC Medical Center /ID# 169516

Novosibirsk, Novosibirsk Oblast, Russia

Site Status

Nort-Western State Medical University n.a. Mechnikov /ID# 207641

Saint Petersburg, Sankt-Peterburg, Russia

Site Status

Kazan State Medical University /ID# 169511

Kazan', Tatarstan, Respublika, Russia

Site Status

Federal Center for Brain and Neurotechnology /ID# 207646

Moscow, , Russia

Site Status

Perm Regional Clinical Hospital /ID# 207642

Perm, , Russia

Site Status

Ulyanovsk Regional Clinical Hospital /ID# 169515

Ulyanovsk, , Russia

Site Status

Institute for Rheumatology /ID# 168194

Belgrade, Beograd, Serbia

Site Status

Institute for Rheumatology /ID# 168197

Belgrade, Beograd, Serbia

Site Status

Institute for Rheumatology /ID# 168198

Belgrade, Beograd, Serbia

Site Status

Institute for Rheumatology /ID# 168199

Belgrade, Beograd, Serbia

Site Status

Military Medical Academy /ID# 168218

Belgrade, Beograd, Serbia

Site Status

Special Hospital for Rheuma /ID# 168255

Novi Sad, Vojvodina, Serbia

Site Status

Special Hospital for Rheuma /ID# 210284

Novi Sad, Vojvodina, Serbia

Site Status

National University Hospital /ID# 208599

Singapore, , Singapore

Site Status

Singapore General Hospital /ID# 207917

Singapore, , Singapore

Site Status

Changi General Hospital /ID# 208965

Singapore, , Singapore

Site Status

REUMA-GLOBAL, s.r.o. /ID# 208017

Biely Kostol, , Slovakia

Site Status

MEDMAN s.r.o. /ID# 208018

Martin, , Slovakia

Site Status

Reum.hapi s.r.o. /ID# 208016

Nové Mesto nad Váhom, , Slovakia

Site Status

Thermium s.r.o. /ID# 208015

Piešťany, , Slovakia

Site Status

REUMAMED POPRAD s.r.o. /ID# 208407

Poprad, , Slovakia

Site Status

Dr Jenny Potts /ID# 168691

Port Elizabeth, Eastern Cape, South Africa

Site Status

University of Pretoria /ID# 167621

Pretoria, Gauteng, South Africa

Site Status

Dr Elsa van Duuren /ID# 207577

Pretoria, Gauteng, South Africa

Site Status

Arthritis Clinical Research Trials /ID# 167625

Cape Town, Western Cape, South Africa

Site Status

Synexus Helderberg Clinical Research Centre /ID# 210891

Somerset West, Western Cape, South Africa

Site Status

Winelands Medical Research Centre /ID# 167629

Stellenbosch, Western Cape, South Africa

Site Status

Hanyang University Seoul Hospital /ID# 209263

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Duplicate_Konkuk University Medical Ctr /ID# 207509

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Kyungpook National Univ Hosp /ID# 207408

Daegu, , South Korea

Site Status

Hospital Universitario Germans Trias i Pujol /ID# 208543

Badalona, Barcelona, Spain

Site Status

Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 207830

Sabadell, Barcelona, Spain

Site Status

Hospital Universitario A Coruna - CHUAC /ID# 207826

A Coruña, , Spain

Site Status

Hospital Universitario Torrecardenas /ID# 212716

Almería, , Spain

Site Status

Hospital Parc de Salut del Mar /ID# 209698

Barcelona, , Spain

Site Status

Hospital Clinico Universitario San Carlos /ID# 207832

Madrid, , Spain

Site Status

Hospital Universitario 12 de Octubre /ID# 207827

Madrid, , Spain

Site Status

Hospital Universitario y Politecnico La Fe /ID# 207831

Valencia, , Spain

Site Status

Skane University hospital /ID# 210070

Malmo, Skåne County, Sweden

Site Status

Falu Lasarett /ID# 210322

Falun, , Sweden

Site Status

Duplicate_Karolinska Univ Sjukhuset /ID# 208175

Solna, , Sweden

Site Status

Uppsala University Hospital /ID# 207944

Uppsala, , Sweden

Site Status

Duplicate_Vastmanlands Sjukhus /ID# 207943

Västerås, , Sweden

Site Status

Orebro Universitetssjukhuset /ID# 207948

Örebro, Örebro County, Sweden

Site Status

Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation /ID# 207567

Chiayi City, , Taiwan

Site Status

Chung Shan Medical University Hospital /ID# 207257

Taichung, , Taiwan

Site Status

Linkou Chang Gung Memorial Ho /ID# 207255

Taoyuan, , Taiwan

Site Status

State Institution L. T. Malaya Therapy National Institution of NAMS of Ukraine /ID# 209556

Kharkiv, Kharkivs’ka Oblast’, Ukraine

Site Status

Scientific Research Institute of Invalid Rehabilitation /ID# 207873

Vinnytsia, Vinnytsia Oblast, Ukraine

Site Status

CNE Cherkasy Regional Hospital of Cherkasy Regional Council /ID# 207912

Cherkasy, , Ukraine

Site Status

MNPE Chernihiv Regional Hospital of the Chernihiv Region Council /ID# 207730

Chernihiv, , Ukraine

Site Status

PNE City Multifunctional Hospital No.18 /ID# 207911

Kharkiv, , Ukraine

Site Status

Khmelnytskyi Regional Hospital /ID# 207753

Khmelnytskyi, , Ukraine

Site Status

MI Kryvyi Rih City Clinical Hospital No.2 /ID# 207748

Kryvyi Rih, , Ukraine

Site Status

Medical Center OK Clinic /ID# 207749

Kyiv, , Ukraine

Site Status

Communal Enterprise Volyn Regional Clinical hospital of the Volyn Regional Coun /ID# 208276

Lutsk, , Ukraine

Site Status

Lviv Municipal City Clinical Hospital #4 /ID# 207715

Lviv, , Ukraine

Site Status

PI "Poltava Regional Clinical Hospital n.a. M.V.Sklifosovsky" /ID# 207872

Poltava, , Ukraine

Site Status

Public Institution 6th City Clinical Hospital /ID# 207754

Zaporizhzhia, , Ukraine

Site Status

Duplicate_Barts Health NHS Trust /ID# 210534

London, London, City of, United Kingdom

Site Status

NHS Greater Glasgow and Clyde /ID# 214942

Glasgow, Scotland, United Kingdom

Site Status

Midlands Partnership NHS Foundation Trust /ID# 214941

Stafford, Staffordshire, United Kingdom

Site Status

Manchester University NHS Foundation Trust /ID# 207928

Manchester, , United Kingdom

Site Status

Duplicate_Wirral University Teaching Hospital NHS Foundation Trust /ID# 210535

Metropolitan Borough of Wirral, , United Kingdom

Site Status

Portsmouth Hospitals University NHS Trust /ID# 207932

Portsmouth, , United Kingdom

Site Status

Torbay and South Devon Nhs Foundation Trust /Id# 207931

Torquay, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Argentina Australia Belgium Bosnia and Herzegovina Brazil Bulgaria Canada Chile Croatia Czechia Denmark Estonia Finland Germany Greece Israel Italy Latvia Lithuania Malaysia Mexico Netherlands New Zealand Poland Portugal Puerto Rico Romania Russia Serbia Singapore Slovakia South Africa South Korea Spain Sweden Taiwan Ukraine United Kingdom

References

Explore related publications, articles, or registry entries linked to this study.

Kristensen LE, Keiserman M, Papp K, McCasland L, White D, Lu W, Wang Z, Soliman AM, Eldred A, Barcomb L, Behrens F. Efficacy and safety of risankizumab for active psoriatic arthritis: 24-week results from the randomised, double-blind, phase 3 KEEPsAKE 1 trial. Ann Rheum Dis. 2022 Feb;81(2):225-231. doi: 10.1136/annrheumdis-2021-221019. Epub 2021 Dec 15.

Reference Type RESULT
PMID: 34911706 (View on PubMed)

Ostor A, Van den Bosch F, Papp K, Keiserman M, Blanco R, Crowley A, White D, Biljan A, Madihlaba T, Carter K, Liu F, Soliman AM, Ashley D, Chen M, Glotfelty L, Kivitz A. Efficacy and Safety of Risankizumab for Active Psoriatic Arthritis: 196-Week Results from the KEEPsAKE 1 and KEEPsAKE 2 Randomized Clinical Trials. Rheumatol Ther. 2025 Sep 30. doi: 10.1007/s40744-025-00793-3. Online ahead of print.

Reference Type DERIVED
PMID: 41028616 (View on PubMed)

Mease PJ, Warren RB, Nash P, Grouin JM, Lyris N, Willems D, Taieb V, Eells J, McInnes IB. Comparative Effectiveness of Bimekizumab and Risankizumab in Patients with Psoriatic Arthritis at 52 Weeks Assessed Using a Matching-Adjusted Indirect Comparison. Rheumatol Ther. 2024 Oct;11(5):1403-1412. doi: 10.1007/s40744-024-00706-w. Epub 2024 Aug 9.

Reference Type DERIVED
PMID: 39120849 (View on PubMed)

Kwatra SG, Khattri S, Amin AZ, Ranza R, Kaplan B, Shi L, Padilla B, Soliman AM, McGonagle D. Enthesitis and Dactylitis Resolution with Risankizumab for Active Psoriatic Arthritis: Integrated Analysis of the Randomized KEEPsAKE 1 and 2 Trials. Dermatol Ther (Heidelb). 2024 Jun;14(6):1517-1530. doi: 10.1007/s13555-024-01174-4. Epub 2024 May 13.

Reference Type DERIVED
PMID: 38739215 (View on PubMed)

Kristensen LE, Keiserman M, Papp K, McCasland L, White D, Carter K, Lippe R, Photowala H, Drogaris L, Soliman AM, Chen M, Padilla B, Behrens F. Efficacy and Safety of Risankizumab for Active Psoriatic Arthritis: 100-Week Results from the Phase 3 KEEPsAKE 1 Randomized Clinical Trial. Rheumatol Ther. 2024 Jun;11(3):617-632. doi: 10.1007/s40744-024-00654-5. Epub 2024 Mar 18.

Reference Type DERIVED
PMID: 38498141 (View on PubMed)

Kristensen LE, Keiserman M, Papp K, McCasland L, White D, Lu W, Soliman AM, Eldred A, Barcomb L, Behrens F. Efficacy and safety of risankizumab for active psoriatic arthritis: 52-week results from the KEEPsAKE 1 study. Rheumatology (Oxford). 2023 Jun 1;62(6):2113-2121. doi: 10.1093/rheumatology/keac607.

Reference Type DERIVED
PMID: 36282530 (View on PubMed)

Thakre N, D'Cunha R, Goebel A, Liu W, Pang Y, Suleiman AA. Population Pharmacokinetics and Exposure-Response Analyses for Risankizumab in Patients with Active Psoriatic Arthritis. Rheumatol Ther. 2022 Dec;9(6):1587-1603. doi: 10.1007/s40744-022-00495-0. Epub 2022 Sep 30.

Reference Type DERIVED
PMID: 36178584 (View on PubMed)

Kristensen LE, Soliman AM, Papp K, White D, Barcomb L, Lu W, Eldred A, Behrens F. Risankizumab improved health-related quality of life, fatigue, pain and work productivity in psoriatic arthritis: results of KEEPsAKE 1. Rheumatology (Oxford). 2023 Feb 1;62(2):629-637. doi: 10.1093/rheumatology/keac342.

Reference Type DERIVED
PMID: 35801915 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

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Document Type: Statistical Analysis Plan

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Document Type: Informed Consent Form

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Related Links

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Other Identifiers

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2017-002465-22

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

M16-011

Identifier Type: -

Identifier Source: org_study_id

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