Effect of Location of Tetanic Stimuli on Photoplethysmogram

NCT ID: NCT03648853

Last Updated: 2020-05-22

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-09-01

Study Completion Date

2018-11-30

Brief Summary

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The effect of the location of tetanic stimulus on photoplethysmography signals will be studies in patients under general anesthesia.

Detailed Description

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A 5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations in a random order in patients who are under general anesthesia. Tetanic stimuli are used routinely during general anesthesia to assess effectiveness of neuromuscular blockade. These tetanic stimuli are noxious stimuli that elicit a stress response which can be quantified using photoplethysmography. This study investigates if the magnitude of the tetanus induced stress response is dependent on the location of the tetanic stimulus as measured by photoplythysmography.

Conditions

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Stress Reaction

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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intervention

all participants receive the same intervention

Group Type EXPERIMENTAL

Tetanic Stimulus

Intervention Type DEVICE

5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations in a random order

Interventions

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Tetanic Stimulus

5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations in a random order

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Surgical patients general anesthesia able to consent in english

Exclusion Criteria

* regional anesthesia unable to consent in english under 18 yrs of age
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of California, San Francisco

OTHER

Sponsor Role lead

Responsible Party

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Pekka Talke

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of California San Francisco

San Francisco, California, United States

Site Status

Countries

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United States

References

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Talke P, Talke I. Effect of the Location of Tetanic Stimulation on Autonomic Responses: A Randomized Cross-Over Pilot Study. J Pain Res. 2024 Jan 9;17:209-217. doi: 10.2147/JPR.S443058. eCollection 2024.

Reference Type DERIVED
PMID: 38223663 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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PT1801

Identifier Type: -

Identifier Source: org_study_id

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