Drug Resistance Among Asymptomatic Infection

NCT ID: NCT03648411

Last Updated: 2020-07-22

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 765 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-01-12
• Study Completion Date: 2020-05-20

Brief Summary

A cross-sectional study will be conducted in selected 2 sentinel sites for assessment of drug resistance falciparum and vivax among asymptomatic infection in migrant workers in Myanmar.

Detailed Description

Although malaria prevalence is decreasing in Myanmar, drug resistance threatens the malaria elimination by 2030 especially high risk persons including migrant population. Previous study indicated that asymptomatic malaria parasite carried drug resistance gene such as K13 mutant that is genetically responsible for artemisinin resistant falciparum malaria. These asymptomatic carries may be a source to spread the disease and it is very important to conduct the surveillance on drug resistance status among high vulnerable persons. Unfortunately, there is no study to assess the drug resistance molecular markers in asymptomatic malaria among migrant workers in Myanmar. Therefore, this study fulfills the gaps of knowledge on important of asymptomatic hidden infection exploring to formulate the recommendation for elimination of malaria in Myanmar.

In this study, asymptomatic infections are screened by rapid diagnostic test, microscopy and molecular methods.

Conditions

Drug Resistant Malaria; Asymptomatic Infections; Migrant Workers

Study Design

• Observational Model Type: ECOLOGIC_OR_COMMUNITY
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Shwegyin

Shwehyin is a Township in Bago Region. We will use the comparison between the two sentinel sites by the name of Shwegyin and Pinlebu. We will compare the prevalence of asymptomatic infection between these two sites. Then proportion of the drug resistance molecular markers will be compared.

Drug resistance molecular markers

Intervention Type: GENETIC

Proportion of the drug resistance molecular markers will be found-out and compared.

Pinlebu

Pinlebu is a township in Sagaing Region. We will use the comparison between the two sentinel sites by the name of Shwegyin and Pinlebu. We will compare the prevalence of asymptomatic infection between these two sites. Then proportion of the drug resistance molecular markers will be compared.

Drug resistance molecular markers

Intervention Type: GENETIC

Proportion of the drug resistance molecular markers will be found-out and compared.

Interventions

Drug resistance molecular markers

Proportion of the drug resistance molecular markers will be found-out and compared.

Intervention Type: GENETIC

Eligibility Criteria

Inclusion Criteria

• Age above 6 year
• Migrant population (moving from their normal residence place and working at a new place such as forest related activities, gold-mines or plantation sites for more than 3 months- 3 years)
• Both sex
• Participant who give informed-consent to participate the study

Exclusion Criteria

• Known clinical malaria cases regardless of the species detected
• Patients with clinical symptoms of malaria at the time of examination
• Known history of malaria within 14 days

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Malaria Control Program, Myanmar

OTHER_GOV

Sponsor Role: collaborator

Department of Medical Research, Lower Myanmar

OTHER

Sponsor Role: lead

Responsible Party

Myat Htut Nyunt

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Myat H Nyunt, PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Medical Research

Locations

Dr. Myat Phone Kyaw

Yangon, , Burma

Countries

Burma

Other Identifiers

DMR_2018-108

Identifier Type: -

Identifier Source: org_study_id