Molecular Assessment of Artemisinin Resistance Markers in Eastern and Western Border Areas of Myanmar
NCT ID: NCT02198573
Last Updated: 2014-07-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
91 participants
OBSERVATIONAL
2013-07-31
2014-06-30
Brief Summary
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* It is important to monitor the spread and magnitude of artemisinin resistant malaria in Myanmar.
* So, day-3 surveillance study have been conducted.
* Recently artemisinin resistant molecular marker, K13 have been identified and it was used as a tool in this study.
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Detailed Description
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Conditions
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Study Design
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PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* age \>2 years
* box sex
* given informed consent
Exclusion Criteria
* did not give informed consent
* others diseases
2 Years
ALL
No
Sponsors
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Kangwon National University
OTHER
Myat Htut Nyunt
OTHER
Responsible Party
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Myat Htut Nyunt
Dr. Myat Htut Nyunt
Principal Investigators
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Myat P Kyaw, PhD
Role: STUDY_DIRECTOR
Department of Medical Research, Lower Myanmar
Locations
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Dr. Myat Phone Kyaw
Yangon, Yangon, Burma
Countries
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References
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World Health Organization. World Malaria Report 2013. Geneva, Switzerland, 2013.
World Health Organization. Global report on antimalarial efficacy and drug resistance: 2000-2010. Geneva, Switzerland: World Health Organization, 2010.
Stepniewska K, Ashley E, Lee SJ, Anstey N, Barnes KI, Binh TQ, D'Alessandro U, Day NP, de Vries PJ, Dorsey G, Guthmann JP, Mayxay M, Newton PN, Olliaro P, Osorio L, Price RN, Rowland M, Smithuis F, Taylor WR, Nosten F, White NJ. In vivo parasitological measures of artemisinin susceptibility. J Infect Dis. 2010 Feb 15;201(4):570-9. doi: 10.1086/650301.
Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, Menard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le Bras J, Berry A, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O, Menard D. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature. 2014 Jan 2;505(7481):50-5. doi: 10.1038/nature12876. Epub 2013 Dec 18.
Singh B, Bobogare A, Cox-Singh J, Snounou G, Abdullah MS, Rahman HA. A genus- and species-specific nested polymerase chain reaction malaria detection assay for epidemiologic studies. Am J Trop Med Hyg. 1999 Apr;60(4):687-92. doi: 10.4269/ajtmh.1999.60.687.
Kyaw MP, Nyunt MH, Chit K, Aye MM, Aye KH, Aye MM, Lindegardh N, Tarning J, Imwong M, Jacob CG, Rasmussen C, Perin J, Ringwald P, Nyunt MM. Reduced susceptibility of Plasmodium falciparum to artesunate in southern Myanmar. PLoS One. 2013;8(3):e57689. doi: 10.1371/journal.pone.0057689. Epub 2013 Mar 8.
Other Identifiers
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WHO_3DF_2013_day3
Identifier Type: -
Identifier Source: org_study_id
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