MedDataX Logo

The Possible Role of Thyroxine in Keratoconus Development

NCT ID: NCT03637673

Last Updated: 2018-08-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-06-01

Study Completion Date

2018-09-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Keratoconus (KC) is a corneal ectatic disorders, with incidence rate 1 per 50,000 among the population. Hormonal imbalances may be associated with KC as it affects the corneal metabolism. In this study, we aim to examine this clinical association between thyroid gland dysfunction (TGD) and KC.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Prevalence Of Keratoconus Among Patients With Thyroid Gland Dysfunction

NCT04346992

Keratoconus in Thyroid Gland Dysfunction
COMPLETED

Corneal Tomographic Parameters in TGD

NCT04433936

Keratoconus Corneal Ectasia Thyroid Eye Disease
COMPLETED

The Effect of Thyroid Hormon Levels on the Corneal Measures

NCT04752969

Thyroid Disorder Corneal Opacity
COMPLETED

The Effect of Teprotumumab on Thyroid Eye Disease and Thyroid Dysfunction

NCT06275373

Thyroid Eye Disease Graves Ophthalmopathy Graves Disease
RECRUITING

AS-OCT of the Cornea in Thyroid Diseases

NCT05241626

Thyroid Eye Disease
UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Keratoconus (KC) is a corneal ectatic disorders, with incidence rate 1 per 50,000 among the population. Moreover, the pathophysiological processes underlying KC have not been fully elucidated with proposed mechanisms to include proteolytic degradation in the corneal stroma, oxidative damage, epithelial mechanical injury, immunological factors, and genetic factors. However, Hormonal imbalances may be associated with KC as it affects the corneal metabolism. Furthermore, thyroid gland dysfunction (TGD) can frequently associated with eye diseases such as Graves disease. Previous studies investigated the association between TGD and KC. Interestingly, thyroxine (T4) is important for corneal dehydration and transparency during embryonic development and regulates the synthesis of keratin sulfate proteoglycan in the chicken. T4 receptors (T4Rs) have been found in the lacrimal gland, confirming that the tear producing gland is a target organ of T4. T4 level was elevated in the tears of patients with KC. Hence, in this study, we aim to investigate the clinical association between TGD and KC.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Keratoconus

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

No intervention

No intervention

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients with KC.

Exclusion Criteria

* Patients who cannot give an informed consent.
* Patients who cannot provide needed samples for any reason
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Alexandria University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Amir abou Samra

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Alexandria Faculty of Medicine

Alexandria, , Egypt

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Egypt

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Amir Abousamra, Ph.D.

Role: CONTACT

[email protected]
00201005084303

Mohamed Fahmy Doheim

Role: CONTACT

[email protected]
001221081590

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Amir Abusamra, Ph.D.

Role: primary

[email protected]
00201005084303

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

5621

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy
NCT01056419 UNKNOWN PHASE4
Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy
NCT03066076 UNKNOWN PHASE3
A Study of Teprotumumab N01 in Subjects With Active Thyroid Eye Disease
NCT07265258 NOT_YET_RECRUITING PHASE4
Role of Levothyroxine Supplementation in Delayed Recovery Following Cardiac Surgery
NCT06660823 COMPLETED PHASE3
The Effect of Thyroid Hormone Levels in Pregnant Women on the Intelligence Quotient (IQ) of Their Children
NCT00147433 UNKNOWN
Throid Dysfunction in Liver Failure and Its Eddects Upon Outcome
NCT06179368 RECRUITING
Effects of Thyroid Hormone Enzyme Blocking on Hypothyroidism
NCT01801033 WITHDRAWN
Euthyroid Sick Syndrome (ESS) Effect on Traumatic Brain Injury Patients and Its Relation With GFAP Level
NCT04806672 UNKNOWN
Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease
NCT02339142 UNKNOWN PHASE4
Factors Affecting Timing of Hypothyroidism Following Radioactive Iodine Therapy Patients With Graves Disease
NCT05643365 UNKNOWN
Natural History of Thyroid Function Disorders
NCT00001159 RECRUITING
Novel Approaches to the Treatment of Hypothyroidism
NCT06731764 RECRUITING PHASE2/PHASE3
The Relation Between Thyroid , Parathyroid Hormones and eGFR in CKD Patients in Assiut
NCT05243979 UNKNOWN
Eltroxin Administration to Patients With Extremely Low T4 Values in the Intensive Care Unit
NCT06154382 RECRUITING
Liver Function After Intravenous Methylprednisolone Administration
NCT03667157 COMPLETED PHASE4
Early Levothyroxine Post Radioactive Iodine
NCT01950260 COMPLETED PHASE2/PHASE3
Quality of Life and Long-term Outcome of Adequately Treated Congenital Hypothyroidism
NCT06864039 ENROLLING_BY_INVITATION NA
A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028)
NCT06625814 COMPLETED PHASE1
Efficacy and Safety of Sequential Hormone Therapy and Tetuzumab Therapy in Patients With Moderate to Severe TAO in the Active Stage After Glucocorticoid Treatment.
NCT07152366 RECRUITING PHASE4
Thyroid-Associated Ophthalmopathy Subtypes and Orbital Antibodies
NCT00430547 COMPLETED NA
Desiccated Thyroid Extract Versus Synthetic T3/T4 Combination (ThyrolarTM) Versus L-T4 Alone in the Therapy of Primary Hypothyroidism With Special Attention to the Gene Polymorphism
NCT02317926 UNKNOWN NA
Characteristics of Islet β-cell Functions in Chinese Patients With Graves' Disease
NCT02376088 COMPLETED
Effective Iodide Therapy for Untreated Patients With Graves' Hyperthyroidism Avoiding Thionamide Drugs With Many Side Effects
NCT04686006 COMPLETED
Desiccated Thyroid Extract and Levothyroxine for Hypothyroidism Treatment
NCT01739972 UNKNOWN NA
Establishment of Multiparametric Prediction Models for Moderate to SevereThyroid Associated Ophthalmopathy
NCT06590220 RECRUITING