GUARD-AKI: Validation of AKI-Sapere in Cardiac Surgery Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

370 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-02-24

Study Completion Date

2023-02-28

Brief Summary

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Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI. The development of CSA-AKI is independently associated with an increased risk of in-hospital death. There are currently no biomarkers that could identify patients at higher risk for AKI and current risk predictor scores that are based on clinical and demographic information are inadequate. Therefore, a diagnostic test for predicting AKI risk in this clinical context would assist clinicians to optimize surgical strategy and postoperative care to prevent CSA-AKI occurrence and improve patient outcomes.

The primary purpose of this study is to validate a panel of biomarkers identified in the discovery study (referred to as AKI-Sapere prognostic) to identify patients at risk for all stages of CSA-AKI.

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Detailed Description

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Conditions

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Coronary Artery Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Adult patients (\>40 years) undergoing non-emergency (urgent or scheduled) cardiac surgery using cardiopulmonary bypass (CABG or combined CABG/valve).
* Patients must be able to understand English and be willing to sign informed consent.

Exclusion Criteria

* Emergency surgery
* Off-pump coronary bypass grafting
* Aortic aneurysm repair
* Congenital heart disease repair
* Heart transplant or left ventricular assist device patient
* Severe heart failure (left ventricular ejection fraction \<25%)
* Hemodynamic instability or requiring preoperative vasopressors or IABP
* Pre-existing kidney disease (eGFR \<30 mL/min/1.73 m2) or renal transplantation.
* Presence of major active infection (chronic or acute, eg, sepsis, HIV, pneumonia)
* Chronic liver disease/cirrhosis
* Participation in an additional trial at the time of surgery or anytime within 30d of surgery where intervention could potentially alter renal health (unless in the control arm)

Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No