The Dual Impact of Homocysteine and Cholesterol on Cognitive Functions
NCT ID: NCT03631238
Last Updated: 2018-08-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
41 participants
OBSERVATIONAL
2018-01-15
2018-08-01
Brief Summary
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Detailed Description
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Some studies suggested that high TC level in old peoples is associated with a decreased risk of dementia.
Other studies have indicated that hypercholesterolemia may be a risk factor for cognitive decline and Alzheimer's disease (AD).
But a recent study published in 2014 by Cheng and colleagues, showed that, an inverse U-shaped relationship between total cholesterol level and cognitive score was found only in participants with normal homocysteine levels. Indicating that both low and high total serum cholesterol were associated with lower cognitive scores, ended to the relationship between cholesterol levels and cognitive function depends upon homocysteine levels, suggesting an interactive role between cholesterol and homocysteine on cognitive function in the elderly peoples.
The effect of high serum homocysteine (HHcy) levels on cognition was overwhelming regardless of the serum cholesterol levels but in peoples with normal homocysteine levels, both low and high cholesterol levels may be detrimental to cognitive health.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Apparently normal participants
Participants are not complaining from any cognitive decline are subjected to cognitive and cholesterol and homocysteine levels assessment.
Blood sampling for total cholesterol and homocysteine and cognitive assessment by psychometric tests.
all participant are subjected to cognitive assessment by psychometric tests by using the arabic version of Mini Mental State Exam (MMSE) and Memory Assessment Scale (MAS).
Blood samples were collected in the morning using 10 mL yellow top (plain) Vacutainer tubes.
Lipid profile (triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)) were measured by Assiut university labs using Cholesterol Kits and analyzed by COBAS Integra analyzer.
Total cholesterol levels were calculated using the sum of the LDL and HDL plus one-fifth of triglyceride levels.
Samples of serum homocysteine are collected, centrifuged to separate plasma within 30 minutes after venipuncture and stored in specialized container in the Department of Clinical Pathology at (-20◦C) temperature.
Total homocysteine was measured by ELISA technique, Sinogen kits (Research Use Only) and Statfax-2100 microplate analyzer.
Interventions
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Blood sampling for total cholesterol and homocysteine and cognitive assessment by psychometric tests.
all participant are subjected to cognitive assessment by psychometric tests by using the arabic version of Mini Mental State Exam (MMSE) and Memory Assessment Scale (MAS).
Blood samples were collected in the morning using 10 mL yellow top (plain) Vacutainer tubes.
Lipid profile (triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)) were measured by Assiut university labs using Cholesterol Kits and analyzed by COBAS Integra analyzer.
Total cholesterol levels were calculated using the sum of the LDL and HDL plus one-fifth of triglyceride levels.
Samples of serum homocysteine are collected, centrifuged to separate plasma within 30 minutes after venipuncture and stored in specialized container in the Department of Clinical Pathology at (-20◦C) temperature.
Total homocysteine was measured by ELISA technique, Sinogen kits (Research Use Only) and Statfax-2100 microplate analyzer.
Eligibility Criteria
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Inclusion Criteria
* Participants are of both genders
* Aged 55 years old and over.
Exclusion Criteria
* Renal and hepatic impairment.
* Parkinson's disease.
* Cerebrovascular stroke.
* Patient with chronic medical problems.
* Patients on statins.
55 Years
ALL
Yes
Sponsors
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Assiut University
OTHER
Responsible Party
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MWAmeen
Principle Investigator
Principal Investigators
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Nageh F El Gamal, MD
Role: STUDY_CHAIR
Assiut University
Locations
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Michael W Ameen
Asyut, , Egypt
Countries
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References
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de Champlain J, Wu R, Girouard H, Karas M, EL Midaoui A, Laplante MA, Wu L. Oxidative stress in hypertension. Clin Exp Hypertens. 2004 Oct-Nov;26(7-8):593-601. doi: 10.1081/ceh-200031904.
Burns JM, Honea RA, Vidoni ED, Hutfles LJ, Brooks WM, Swerdlow RH. Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging. Biochim Biophys Acta. 2012 Mar;1822(3):333-9. doi: 10.1016/j.bbadis.2011.06.011. Epub 2011 Jul 1.
Cheng Y, Jin Y, Unverzagt FW, Su L, Yang L, Ma F, Hake AM, Kettler C, Chen C, Liu J, Bian J, Li P, Murrell JR, Hendrie HC, Gao S. The relationship between cholesterol and cognitive function is homocysteine-dependent. Clin Interv Aging. 2014 Oct 23;9:1823-9. doi: 10.2147/CIA.S64766. eCollection 2014.
Ansari R, Mahta A, Mallack E, Luo JJ. Hyperhomocysteinemia and neurologic disorders: a review. J Clin Neurol. 2014 Oct;10(4):281-8. doi: 10.3988/jcn.2014.10.4.281. Epub 2014 Oct 6.
Other Identifiers
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Cholesterol and cognition
Identifier Type: -
Identifier Source: org_study_id
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