Medication Adherence in Patients With Liver Cirrhosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-09-01

Study Completion Date

2021-05-31

Brief Summary

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With this unfunded, investigator-initiated prospective, observational, explorative, single-arm and diagnostic single-centre study the investigators aim to evaluate medication adherence in patients with advanced liver cirrhosis

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Detailed Description

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The main objective of the study is to investigate drug adherence in cirrhotic patients and to gain a better understanding of the causes of deficient adherence including evaluation for medication beliefs, satisfaction, depression, anxiety and health-related quality of life. A number of long-term medications have been approved for this group of patients in various indications and / or recommended by guidelines. However, adherence has not been adequately investigated yet. The investigators aim to focus on the following groups of ingredients / classes:

* Primary and secondary antibiotic prophylaxis (e.g. Norfloxacin)
* Non-selective beta-blockers (e.g. Carvedilol and Propranolol)
* diuretics (Spirolactones \[e.g. Spironolacton\], loop diuretics) Methodically, this is will be investigated in particular by taking into account the patients history, standardized questionnaires and validated interviews.

Conditions

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Medication Adherence

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Norfloxacin

evaluate medication adherence, patient history, medication beliefs and medication satisfaction, depression, anxiety and health-related quality of life

questionaire, interview

Intervention Type DIAGNOSTIC_TEST

questionaire, interview

Non-selective beta blockers

evaluate medication adherence, patient history, medication beliefs and medication satisfaction, depression, anxiety and health-related quality of life

questionaire, interview

Intervention Type DIAGNOSTIC_TEST

questionaire, interview

diuretics

evaluate medication adherence, patient history, medication beliefs and medication satisfaction, depression, anxiety and health-related quality of life

questionaire, interview

Intervention Type DIAGNOSTIC_TEST

questionaire, interview

Interventions

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questionaire, interview

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Treatment at Dept. of Gastroenterology, Hepatology and Endocrinology at Med. School of Hannover
* Liver cirrhosis
* Written consent for the use of personal data and health data for the purpose of this study