Effects of Early Stepping Verticalization + FES on CIP

NCT ID: NCT03616314

Last Updated: 2018-08-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

39 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-06-01

Study Completion Date

2018-07-01

Brief Summary

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Background: Intensive Care Unit (ICU) survivors often develop an acquired weakness due to a Critical Illness Polyneuropathy (CIP). Early mobilization in ICU, by reducing the bed rest and decreasing the oxidative stress, was shown to represent a valid preventive option.

Purpose: To evaluate whether ICU sessions of stepping verticalization associated with Functional Electrical Stimulation (FES) of the lower limbs are able to reduce the occurrence of CIP in Acquired Brain Injured (ABI) patients.

Methods: all the ABI patients admitted in our Neurorehabilitation Unit from our ICU were retrospectively evaluated. Patients affected by previous peripheral neuropathy, diabetes, cancer, alcoholism, viral hepatitis, AIDS and autoimmune diseases were excluded. They were divided into 3 groups according to the rehabilitation strategy received in ICU: group 1 received conventional physiotherapy + stepping verticalization sessions with Erigo® (Hocoma, Switzerland); group 2 received conventional physiotherapy + stepping verticalization sessions with FES using ErigoPro®; group 3 received only conventional physiotherapy. As for internal protocol, all patients started rehabilitation in the first week from the ABI and performed 60 minutes/day of rehabilitation, 5 days/week. Primary outcome was the evidence of CIP at Neurorehabilitation admission (=ICU discharge), according to neurophysiological criteria. Secondary outcomes were the strength impairment at Neurorehabilitation discharge, measured by the total Motricity Index score and the Functional Ambulation Classification (FAC) score, assessing quality of gait.

Detailed Description

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Conditions

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Critical Illness Polyneuropathy Acquired Brain Injury

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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stepping verticalization

in ICU they received conventional physiotherapy + stepping verticalization sessions with Erigo

stepping verticalization

Intervention Type DEVICE

patients receive 30 minutes/day of conventional physiotherapy + 30 minutes7day of verticalization using a tilt table with a robotic stepping device

stepping verticalization + FES

in ICU they received conventional physiotherapy + stepping verticalization sessions with FES using ErigoPro

stepping verticalization plus functional electrical stimulation

Intervention Type DEVICE

patients hospitalized in ICU are rehabilitated using 30 minutes/day of conventional physiotherapy + 30 minutes/day of verticalization using a tilt table with an integrated robotic stepping device synchronized with an electrical stimulation of the lower limbs muscles

conventional physiotherapy

in ICU they received only conventional physiotherapy

conventional physiotherapy

Intervention Type OTHER

patients are treated only with 60 minutes/day of conventional physiotherapy

Interventions

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stepping verticalization plus functional electrical stimulation

patients hospitalized in ICU are rehabilitated using 30 minutes/day of conventional physiotherapy + 30 minutes/day of verticalization using a tilt table with an integrated robotic stepping device synchronized with an electrical stimulation of the lower limbs muscles

Intervention Type DEVICE

stepping verticalization

patients receive 30 minutes/day of conventional physiotherapy + 30 minutes7day of verticalization using a tilt table with a robotic stepping device

Intervention Type DEVICE

conventional physiotherapy

patients are treated only with 60 minutes/day of conventional physiotherapy

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* arriving directly from our acute care facility
* hospitalized in ICU due to an acute brain injury

Exclusion Criteria

* previous peripheral neuropathies
* diabetes
* cancer
* alcoholism
* viral hepatitis
* AIDS
* autoimmune diseases
* absence of clinical or neurophysiological informations at data collection
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ospedale Generale Di Zona Moriggia-Pelascini

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Ospedale Generale di Zona Moriggia Pelascini

Gravedona, CO, Italy

Site Status

Countries

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Italy

Other Identifiers

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Erigo/FES critical illness

Identifier Type: -

Identifier Source: org_study_id

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