Trunk Task-oriented Training Combined With Functional Electrical Stimulation in Spinal Cord Injured Individuals

NCT ID: NCT05196204

Last Updated: 2022-01-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-11

Study Completion Date

2022-10-31

Brief Summary

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The objectives of the study are to evaluate trunk task-oriented training combined with function electrical stimulation (FES/T-TOT) efficacy on sitting balance and functional independence, and to understand the mechanisms of neuroplasticity that would improve functional independence following FES/T-TOT in individuals with spinal cord injury.

Detailed Description

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After obtaining their consent, participants will undertake evaluations at different times:

1. Assessment 3 weeks prior to training
2. Assessment 1 week prior to training
3. Training over 12 weeks
4. Assessment 1 week after training
5. Assessment 1 month after training (follow-up)

Each assessment will be divided in 2 sessions and data will be collected over 2 days, at one session per day. The assessment will consist of:

* Session 1 (at Neuro-Concept clinic) will include presentation of the study and the obtention of written consent, clinical (modified Reaching test and muscle strength), quality of life and functional independence assessments.
* Session 2 (at IURDPM in Dr. Barthélemy's laboratory) will include postural control, corticospinal and cortical assessments.

After the initial assessment, the participants with spinal cord injury will realize 36 sessions of trunk task-oriented training alone or combined with function electrical stimulation (3 times a week for 12 weeks).

Conditions

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Spinal Cord Injuries

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Trunk-oriented task combined with functional electrical stimulation training group

This group will be formed with participants with spinal cord injury. This group will perform 12 weeks of trunk-oriented task training combined with functional electrical stimulation.

Group Type EXPERIMENTAL

Trunk-oriented task training combined with functional electrical stimulation

Intervention Type OTHER

Training will consist to perform one hour of trunk task-oriented training combined with functional electrical stimulation (FES/T-TOT) specific for muscle strength and motor control. All training will be done seated without support with knees and hips flexed to 90 degrees. FES will be combined with functional and non-functional tasks to work functionality and muscle strengthening. Each training session will consist on the fulfilment of two functional tasks (as reaching) and two non-functional tasks (as push-up movement) from a battery of postural control exercises.

Trunk-oriented task training group

This group will be formed with participants with spinal cord injury. This group will perform 12 weeks of trunk-oriented task training.

Group Type ACTIVE_COMPARATOR

Trunk-oriented task training alone

Intervention Type OTHER

The SCI participants who will perform T-TOT training alone will have to perform the same exercises as explained in the previous section (two functional tasks and two non-functional tasks) but they will not receive any functional electrical stimulation.

Training will consist to perform one hour of trunk task-oriented training (T-TOT) specific for muscle strength and motor control. All training will be done seated without support with knees and hips flexed to 90 degrees. Each training session will consist on the fulfilment of two functional tasks (as reaching) and two non-functional tasks (as push-up movement) from a battery of postural control exercises.

Control group

Healthy participants will be recruited based on the age and sex of the participants with spinal cord injury to realize clinical, biomechanical and cortical evaluations

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Trunk-oriented task training combined with functional electrical stimulation

Training will consist to perform one hour of trunk task-oriented training combined with functional electrical stimulation (FES/T-TOT) specific for muscle strength and motor control. All training will be done seated without support with knees and hips flexed to 90 degrees. FES will be combined with functional and non-functional tasks to work functionality and muscle strengthening. Each training session will consist on the fulfilment of two functional tasks (as reaching) and two non-functional tasks (as push-up movement) from a battery of postural control exercises.

Intervention Type OTHER

Trunk-oriented task training alone

The SCI participants who will perform T-TOT training alone will have to perform the same exercises as explained in the previous section (two functional tasks and two non-functional tasks) but they will not receive any functional electrical stimulation.

Training will consist to perform one hour of trunk task-oriented training (T-TOT) specific for muscle strength and motor control. All training will be done seated without support with knees and hips flexed to 90 degrees. Each training session will consist on the fulfilment of two functional tasks (as reaching) and two non-functional tasks (as push-up movement) from a battery of postural control exercises.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Level of spinal cord lesion between C6/C7 and T10
* At least, 6 months post-injury
* Be considered as AIS A, B, C or D
* Be able to sit without support for 15 seconds
* Be able to provide informed consent in English or in French

Exclusion Criteria

* To have cognitive deficits
* To wear a corset
* To have personal or family history of epilepsy
* To have suffered moderate or severe traumatic brain injury
* To have cochlear implant

FOR CONTROL PARTICIPANTS


* To have orthopedics problems
* To have cognitive deficits
* To have neurological problems
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Mitacs

INDUSTRY

Sponsor Role collaborator

Neuro-Concept Inc.

UNKNOWN

Sponsor Role collaborator

Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal

OTHER

Sponsor Role lead

Responsible Party

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Dorothy Barthélemy

Associate professor and researcher

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Neuro-Concept Inc

Montreal, Quebec, Canada

Site Status RECRUITING

Neuromobility lab

Montreal, Quebec, Canada

Site Status ENROLLING_BY_INVITATION

Countries

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Canada

Central Contacts

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Dorothy Barthélemy, PhD, PT

Role: CONTACT

514-343-7712

Charlotte Pion, PhD, Kin

Role: CONTACT

438-490-8512

Facility Contacts

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Charlotte Pion, PhD, Kin

Role: primary

438-490-8512

Other Identifiers

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CRIR-1497-1020

Identifier Type: -

Identifier Source: org_study_id

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