Plant-based Diets and Risk of Cancer in the Adventist Health Study-2

NCT ID: NCT03615599

Last Updated: 2025-01-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

96000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2002-02-01

Study Completion Date

2028-12-31

Brief Summary

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The Adventist Health Study-2 is a long-term study, exploring the links between lifestyle, diet, and disease outcomes among Seventh-day Adventists. More than 96,000 church members from the U.S. and Canada are participating in the current study, AHS-2, conducted by researchers at the Loma Linda University School of Public Health.

Detailed Description

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The Adventist Health Study-2 (AHS-2) is a large national cohort of 96,000 Seventh-day Adventists in the U.S. and Canada. The study is searching for associations between diet and risk of common and medium frequency cancers (breast, prostate, colorectal, lung, uterus, pancreas, melanoma of skin). This cohort is unusual in that about half are vegetarian, many eat soy at Asian levels, and many have very low or absent dairy intake while others eat normal amounts of dairy. Thus observations on these people, many of whom have contrasting dietary habits, may provide insights about diet and cancer, so supporting dietary changes that could be readily adopted by many.

Conditions

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Cancer, Breast Cancer, Colorectal Cancer, Prostate

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Seventh-day Adventists

This is a prospective cohort study of 96,000 members of the Seventh-day Adventists Church in the United States and Canada age 30 and older at the time of enrollment who are proficient in English language.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Member of a Seventh-day Adventist church \>30 years of age Ability to read English Live in the US or Canada

Exclusion Criteria

* Less than 30 years of age
* Church members who did not complete the baseline questionnaire.
* Incarcerated or institutionalized people
* Non-English speakers
Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

World Cancer Research Fund International

OTHER

Sponsor Role collaborator

Ardmore Institute of Health

OTHER

Sponsor Role collaborator

Loma Linda University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gary E Fraser, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Loma Linda University

Locations

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Loma Linda University

Loma Linda, California, United States

Site Status

Countries

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United States

References

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Butler TL, Fraser GE, Beeson WL, Knutsen SF, Herring RP, Chan J, Sabate J, Montgomery S, Haddad E, Preston-Martin S, Bennett H, Jaceldo-Siegl K. Cohort profile: The Adventist Health Study-2 (AHS-2). Int J Epidemiol. 2008 Apr;37(2):260-5. doi: 10.1093/ije/dym165. Epub 2007 Aug 27. No abstract available.

Reference Type BACKGROUND
PMID: 17726038 (View on PubMed)

Fraser GE, Jacobsen BK, Knutsen SF, Mashchak A, Lloren JI. Tomato consumption and intake of lycopene as predictors of the incidence of prostate cancer: the Adventist Health Study-2. Cancer Causes Control. 2020 Apr;31(4):341-351. doi: 10.1007/s10552-020-01279-z. Epub 2020 Feb 25.

Reference Type DERIVED
PMID: 32100191 (View on PubMed)

Other Identifiers

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U01CA152939

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R01CA094594

Identifier Type: NIH

Identifier Source: secondary_id

View Link

48134

Identifier Type: -

Identifier Source: org_study_id

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