Effect of Topical Tetracycline and Dexamethasone on Periodontal and Pulpal Regeneration of Replanted Avulsed Teeth

NCT ID: NCT03611920

Last Updated: 2018-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

33 participants

Study Classification

OBSERVATIONAL

Study Start Date

2000-08-14

Study Completion Date

2017-10-05

Brief Summary

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To evaluate the effect of topical tetracycline and dexamethasone on periodontal and pulpal regeneration of avulsed permanent teeth after an observation period between 9-16 years.

Detailed Description

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Two different medications were applied prior to replantation. A) Topical tetracycline, B) topical dexamethasone. Teeth were splinted using a non-rigid titanium trauma splint for 7-14 days. Endodontic treatment was performed within 1-7 days, except for teeth with an open apex and a short extraoral dry time. All patients received systemic tetracycline for 10 days after accident and were subsequently re-examined.

Follow-up examinations included periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow, periapical radiograph and intraoral photographs. Additionally a OHIP-14 questionnaire was carried out to determine the oral health-related quality of life.

Conditions

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Dental Trauma Avulsion Periodontal Regeneration Pulpal Regeneration Topical Dexamethasone Topical Tetracycline

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Tetracycline

Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation

Tetracycline

Intervention Type PROCEDURE

Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation

Dexamethasone

Teeth were soaked in dexamethasone (60μ ml-1) for 20 minutes before replantation

Dexamethasone

Intervention Type PROCEDURE

Teeth were soaked in topical dexamethasone (60μ ml-1) for 20 minutes before replantation

Interventions

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Tetracycline

Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation

Intervention Type PROCEDURE

Dexamethasone

Teeth were soaked in topical dexamethasone (60μ ml-1) for 20 minutes before replantation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Avulsion of a permanent tooth
* Written informed consent

Exclusion Criteria

* Extended dry period of more than 60 minutes
Minimum Eligible Age

6 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Bern

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Vivianne Chappuis, PD Dr.

Role: STUDY_CHAIR

Department of Oral Surgery and Stomatology, zmk Bern, University Bern

Locations

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zmk Bern

Bern, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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KEK: 2016-00383

Identifier Type: -

Identifier Source: org_study_id

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