Modulation of Repetitive Transcranial Magnetic Stimulation on Hippocampal Neurogenesis and Functional Network in Patients With Schizophrenia
NCT ID: NCT03608462
Last Updated: 2021-09-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
180 participants
INTERVENTIONAL
2019-04-01
2021-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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rTMS targeting the right DLPFC
60 patients will be randomly allocated into this group,half of them will receive iTBS on the right DLPFC,while the other half will receive sham stimulation.
repetitive transcranial magnetic stimulation(DLPFC)
high frequency(20Hz) repetitive transcranial magnetic stimulation on dorsolateral prefrontal cortex(DLPFC) .Duration:10 days.
rTMS targeting the left LPC
60 patients will be randomly allocated into this group,half of them will receive iTBS on left LPC,while the other half will receive sham stimulation.
repetitive transcranial magnetic stimulation(LPC)
high frequency(20Hz) repetitive transcranial magnetic stimulation on left parietal cortex(LPC).Duration:10 days
Observation group
To investigate the abnormalities of hippocampal neurogenesis in patients with early schizophrenia(n=30) compared to healthy controls(n=30)
No interventions assigned to this group
Interventions
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repetitive transcranial magnetic stimulation(DLPFC)
high frequency(20Hz) repetitive transcranial magnetic stimulation on dorsolateral prefrontal cortex(DLPFC) .Duration:10 days.
repetitive transcranial magnetic stimulation(LPC)
high frequency(20Hz) repetitive transcranial magnetic stimulation on left parietal cortex(LPC).Duration:10 days
Eligibility Criteria
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Inclusion Criteria
2. Meet the diagnostic criteria of Diagnostic and Statistical Manual Diploma in Social Medicine(DSM-V) schizophrenia or schizophreniform psychosis.
3. 18-50years of age,right-handed,normal vision or corrected vision, Han nationality.
4. Disease course less than 5 years.
5. Written informed consent
Observation group: First-episode, In addition to criteria1-3,5,antipsychotics naïve,or antipsychotics withdrawal for more than 3 months.
Intervention group:In addition to criteria 1-6,currently under medication and medically stable for at least 1 month(PANSS score fluctuation\<10%);continue the original antipsychotics for at least 1 months after recruitment,with consent of the patients,their psychiatrists and family members.
1. The Structured Interview for Prodromal Symptoms (SIPS) was employed
2. Matched to the early schizophrenia group in terms of age,sex ratio,handedness,and estimated premorbid IQ
3. normal vision or corrected vision, Han nationality
4. Written informed consent
Exclusion Criteria
* Healthy controls:
History of psychiatric disease in the subjects themselves or a family history of mental disorder in their first-degree relatives,neurological illness,severe physical illness,substance abuse or alcohol dependence,mental retardation.
18 Years
50 Years
ALL
Yes
Sponsors
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Shanghai Jiao Tong University School of Medicine
OTHER
Shanghai Mental Health Center
OTHER
Responsible Party
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Locations
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Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Countries
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References
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Li X, Xiang Q, Cen H, Zhai Z, Gao T, Lu C, Dong Y, Ye Y, Zhang C, Zhuo K, Wang Y, Liu D. Efficacy of Cortical-Hippocampal Target Intermittent Theta Burst Stimulation (iTBS) on Associative Memory of Schizophrenia: A Double-Blind, Randomized Sham-Controlled Trial. Neuropsychiatr Dis Treat. 2024 Oct 10;20:1941-1955. doi: 10.2147/NDT.S468219. eCollection 2024.
Other Identifiers
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YG2017ZD13
Identifier Type: -
Identifier Source: org_study_id
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