Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2018-07-25
2018-09-10
Brief Summary
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Detailed Description
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The vasodilatator nitric-oxide (NO) donor will be used to trigger remote effect on gingiva. NO donor solutions will be applied in 1 mg/ml and 8 mg/ml nitroglycerin concentrations. Solution will be dropped on the gingiva at tooth 12 in a fabricated leakage proof well attached to 2mm above the marginal gingiva. The change on blood flow will be monitor at the test well with surrounding gingival area spanning 3 tooth and at the contralateral side by LSCI.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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8 mg/ml nitroglycerin
Higher concentration of NO donor (Nitromint) vs dilution
nitroglycerin
Vasodilatator solution is dropped on the gingiva.
1 mg/ml nitroglycerin
Lower concentration of NO donor (Nitropohl) vs physiological saline
nitroglycerin
Vasodilatator solution is dropped on the gingiva.
Interventions
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nitroglycerin
Vasodilatator solution is dropped on the gingiva.
Eligibility Criteria
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Inclusion Criteria
* minimum 5 mm keratinized gingiva at upper front teeth
Exclusion Criteria
* medication (except contraceptives)
* smoking
* periodontitis
* caries
* insufficient marginal integrity
18 Years
45 Years
ALL
Yes
Sponsors
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Semmelweis University
OTHER
Responsible Party
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Dr. Vag Janos
Principal Investigator
Locations
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Janos Vag
Budapest, , Hungary
Countries
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Other Identifiers
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5/2018
Identifier Type: -
Identifier Source: org_study_id
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