Variables Predicting Reintubation After Thymectomy in Patients With Myasthenia Gravis

NCT ID: NCT03597373

Last Updated: 2018-07-24

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 99 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-01-01
• Study Completion Date: 2019-01-01

Brief Summary

Myasthenia gravis (MG) is an autoimmune disease that is characterized by muscle weakness and fatigue. The role of the thymus in MG has been suggested by the evidence that 10% to 15% of patients present with a thymoma and at least 60% with thymus hyperplasia or dysplasia.Beneficial effects of thymectomy in patients with MG have been described in 40% to 90%.Few studies have looked at the incidence of reintubation (not just within 24 hours after extubation), the factors associated with reintubation, and patient outcome.

Premature extubation may lead to hypercarbia, hypoxemia, pulmonary hypertension, right heart failure, and myocardial ischemia. Additionally, it subjects the patient to the physical risks of reintubation, including esophageal intubation, laryngeal trauma, and pulmonary aspiration. The purpose of the present study was to determine the incidence of reintubation, the variables associated with reintubation, and patient outcome

Detailed Description

Inclusion was based on the availability of all the following possible predictive pre-operative variables: age, gender, weight, height, body mass index, diabetes, creatinine, duration of MG, severity of MG (based on Osserman's classification), pathological type of MG, history of myasthenic crisis, dose of pyridostigmine, use of a steroid hormone, and use of an immunosuppressant.operative variables: postoperative pulmonary infection, total duration of hospital stay, duration of ICU stay, and duration of postoperative hospital stay. Variables were collected by research assistants and maintained in a computer database.

Conditions

Myasthenia Gravis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

reintubation

Reestablish of invasive mechanical ventilation

reintubation

Intervention Type: OTHER

Reintubation was defied by the reinstitution of invasive mechanical ventilation following extubation at any time

not reintubation

Favourable respiratory function

reintubation

Intervention Type: OTHER

Reintubation was defied by the reinstitution of invasive mechanical ventilation following extubation at any time

Interventions

reintubation

Reintubation was defied by the reinstitution of invasive mechanical ventilation following extubation at any time

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• younger than 75 years
• absence of heart failure as the primary indication for mechanical ventilation •Acute Physiology and Chronic Health Evaluation (APACHE) II score less than 12 points on day of extubation
• body mass index less than 30

Exclusion Criteria

•preoperative moderate-to-severe chronic obstructive pulmonary disease

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

First Affiliated Hospital, Sun Yat-Sen University

OTHER

Sponsor Role: lead

Responsible Party

GengLong Liu

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Genglong Liu

Role: PRINCIPAL_INVESTIGATOR

First Affiliated Hospital, Sun Yat-Sen University

Locations

Genglong Liu

Guangzhou, Guangdong, China

Site Status: RECRUITING

Countries

China

Central Contacts

Genglong Liu

Role: CONTACT

lglong3@mail2.sysu.edu.cn

+8615626405844

Facility Contacts

Genglong Liu, MD

Role: primary

Other Identifiers

Reintubation

Identifier Type: -

Identifier Source: org_study_id