BlueWind RENOVA iStim™ System for the Treatment of OAB

NCT ID: NCT03596671

Last Updated: 2025-09-16

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

282 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-06-12

Study Completion Date

2025-01-24

Brief Summary

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The OASIS study is prospective, interventional, multi-center study to evaluate the safety and efficacy of the BlueWind RENOVA iStim™ implantable tibial neuromodulation System for the treatment of patients diagnosed with overactive bladder.

Detailed Description

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Conditions

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Treatment of Patients Suffering From Overactive Bladder (OAB)

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment arm

RENOVA iStim™ System implanted patients

Group Type EXPERIMENTAL

RENOVA iStim™ System

Intervention Type DEVICE

Tibial implantable neuromodulation device

Interventions

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RENOVA iStim™ System

Tibial implantable neuromodulation device

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Female aged 18 or greater (21 in the US)
* More than or equal to 6 months history of UUI diagnosis
* Patient who is mentally competent with the ability to understand and comply with the requirements of the study

Exclusion Criteria

* Any significant medical condition that is likely to interfere with study procedures
* Patients who are breastfeeding
* Predominant stress incontinence
* Have a life expectancy of less than 1 year
* Diagnosis of interstitial cystitis or bladder pain syndrome as defined by either American Urological Association (AUA) or European Association of Urology (EAU) guidelines
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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BlueWind Medical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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John Heesakkers, MD

Role: PRINCIPAL_INVESTIGATOR

Maastricht University Medical Centre

Locations

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University of California Irvine

Orange, California, United States

Site Status

Kaiser Permanente

San Diego, California, United States

Site Status

Norwalk Urology

Norwalk, Connecticut, United States

Site Status

Florida Urology Partners

Tampa, Florida, United States

Site Status

Comprehensive Urologic Care

Lake Barrington, Illinois, United States

Site Status

Regional Urology, LLC

Shreveport, Louisiana, United States

Site Status

Chesapeake Urology - Hanover

Hanover, Maryland, United States

Site Status

Chesapeake Urology - Owing Mills

Owings Mills, Maryland, United States

Site Status

Minnesota Urology

Woodbury, Minnesota, United States

Site Status

Adult Pediatric Urology & Urogynecology

Omaha, Nebraska, United States

Site Status

Duke Urogynecology

Durham, North Carolina, United States

Site Status

Southern Urogynocology

West Columbia, South Carolina, United States

Site Status

Sanford Health

Sioux Falls, South Dakota, United States

Site Status

University of Washington

Seattle, Washington, United States

Site Status

University Hospital Antwerp

Antwerp, , Belgium

Site Status

UZ Leuven

Leuven, , Belgium

Site Status

Rijnstate Hospital

Arnhem, , Netherlands

Site Status

Academic Hospital Maastricht

Maastricht, , Netherlands

Site Status

Radboud University Medical Center

Nijmegen, , Netherlands

Site Status

UMC Utrecht

Utrecht, , Netherlands

Site Status

Isala

Zwolle, , Netherlands

Site Status

Birmingham Women's and Children's NHS Foundation Trust

Birmingham, , United Kingdom

Site Status

Imperial College, St. Mary's Hospital

London, , United Kingdom

Site Status

Countries

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United States Belgium Netherlands United Kingdom

References

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Heesakkers JPFA, Toozs-Hobson P, Sutherland SE, Digesu A, Amundsen CL, McCrery RJ, De Wachter S, Kean ER, Martens F, Benson K, Ferrante KL, Cline KJ, Padron OF, Giusto L, Lane FL, Witte LPW, Dmochowski RR. Two-Year Efficacy and Safety Outcomes of the Pivotal OASIS Study Using the Revi System for Treatment of Urgency Urinary Incontinence. J Urol. 2025 Mar;213(3):323-332. doi: 10.1097/JU.0000000000004328. Epub 2024 Nov 25.

Reference Type DERIVED
PMID: 39585851 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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G02-CLP-0002

Identifier Type: -

Identifier Source: org_study_id

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