Diuretic Response in Advanced Heart Failure: Bolus Intermittent vs Continuous INfusion
NCT ID: NCT03592836
Last Updated: 2018-07-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
80 participants
INTERVENTIONAL
2013-05-01
2017-12-22
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Continuous infusion of loop diuretics
Furosemide continuous infusion: 125 or 250 mg die
Loop Diuretics
intravenous administration of diuretics
Intermittent infusion of loop diuretics
Furosemide bolus intermittent: 125 or 250 mg die
Loop Diuretics
intravenous administration of diuretics
Interventions
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Loop Diuretics
intravenous administration of diuretics
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* WET ≥ 12
* Systolic blood pressure ≤ 110 mmHg
* Serum sodium ≤ 135 mEq/L
* Left systolic ventricular insufficiency (FE \< 35%) note for at least 6 months
* Class NYHA III-IV despite medical treatment maximal
Exclusion Criteria
* Shock cardiogenic
* Chronic renal failure stage V
18 Years
ALL
No
Sponsors
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University of Turin, Italy
OTHER
Responsible Party
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Simone Frea
MD, Cardiologist
Principal Investigators
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Simone Frea, MD
Role: PRINCIPAL_INVESTIGATOR
A.O.U. Città della Salute e della Scienza di Torino
Locations
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Simone Frea
Torino, To, Italy
Countries
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References
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Frea S, Pidello S, Volpe A, Canavosio FG, Galluzzo A, Bovolo V, Camarda A, Golzio PG, D'Ascenzo F, Bergerone S, Rinaldi M, Gaita F. Diuretic treatment in high-risk acute decompensation of advanced chronic heart failure-bolus intermittent vs. continuous infusion of furosemide: a randomized controlled trial. Clin Res Cardiol. 2020 Apr;109(4):417-425. doi: 10.1007/s00392-019-01521-y. Epub 2019 Jun 29.
Other Identifiers
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DRAIN trial
Identifier Type: -
Identifier Source: org_study_id
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