The Potential Role Of MicroRNA-155 And Telomerase Reverse Transcriptase In Diagnosis Of Non-Muscle Invasive Bladder Cancer And Their Pathological Correlation

NCT ID: NCT03591367

Last Updated: 2019-11-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

115 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-08-01

Study Completion Date

2019-05-01

Brief Summary

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We try to assess the potential role of telomerase reverse transcriptase and MicroRNA (miR-155) in diagnosis of non-muscle-invasive bladder cancer and their correlation with stage and grade of the tumor.

Detailed Description

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Conditions

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Bladder Cancer Bladder Disease Bladder Neoplasm Micro-RNA

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Hematuria due to suspicious superficial bladder tumor

MicroRNAs-155 (miRNAs-155) and Human telomerase reverse transcriptase (hTERT)

Group Type OTHER

MicroRNAs-155

Intervention Type DIAGNOSTIC_TEST

Quantitative analysis of cell-free miR-155 using RT-qPCR.

Human telomerase reverse transcriptase

Intervention Type DIAGNOSTIC_TEST

Analysis TERT by TERT messenger RNA (mRNA)expression by reverse transcription-quantitative polymerase chain reaction.

Interventions

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MicroRNAs-155

Quantitative analysis of cell-free miR-155 using RT-qPCR.

Intervention Type DIAGNOSTIC_TEST

Human telomerase reverse transcriptase

Analysis TERT by TERT messenger RNA (mRNA)expression by reverse transcription-quantitative polymerase chain reaction.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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(miRNAs-155) (hTERT)

Eligibility Criteria

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Inclusion Criteria

* Men and women 18 years or older.
* Patient with hematuria suspected to be of bladder origin clinically.
* Willing to be participate in the study.

Exclusion Criteria

* Patient having another malignancy.
* Hematuria of other causes as trauma and stones
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mansoura University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ahmed Mosbah, MD

Role: STUDY_CHAIR

Urology and nephrology center

Locations

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Urology and Nephrology Center

Al Mansurah, Aldakahlia, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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MicroRNA-155 Bladder Cancer

Identifier Type: -

Identifier Source: org_study_id

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