Specimen Repository for HIV Immunopathogenesis

NCT ID: NCT03579381

Last Updated: 2021-01-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

9 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-07-31

Study Completion Date

2019-01-25

Brief Summary

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Specimen Repository for HIV Immunopathogenesis Studies

Detailed Description

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The goal is to build a large specimen repository for collaborating scientists to run studies of immunity and HIV-1.

Conditions

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HIV-1-infection Acute HIV Infection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Immune Controllers

Patients with very low or undetectable levels of viremia without treatment

No interventions assigned to this group

Acute Infection

Early infection, i.e. within 2 weeks of infection

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. HIV positive (acutely infected, viremic and elite controllers)
2. Signed Informed Consent Form
3. Age at least 18 years old
4. Immune controllers, two types: "Elite suppressors" (HIV-positive with any three consecutive plasma HIV-1 RNA PCR undetectable while off treatment) or "viremic suppressors" (HIV-positive with any three consecutive HIV-1 RNA PCR \<3000 while off treatment).
5. Acutely infected subjects:

Persons identified to have a negative HIV antibody response (ELISA) but positive detection of HIV-1 in the blood (RT-PCR) or individuals who have evidence of a recent (past 30 days) HIV negative result along with a current HIV positive result.

Exclusion Criteria

1. Uncontrolled bleeding diathesis.
2. Pregnant.
3. Inability to provide informed consent.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of California, Los Angeles

OTHER

Sponsor Role collaborator

AIDS Healthcare Foundation

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Otto O Yang, MD

Role: STUDY_DIRECTOR

Scientific Director

Locations

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AIDS Healthcare Foundation - Public Health Division

Los Angeles, California, United States

Site Status

Countries

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United States

Other Identifiers

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AHF 03

Identifier Type: -

Identifier Source: org_study_id

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