Hyperoxia Before and After Cardiac Arrest and Myocardial Damage
NCT ID: NCT03571074
Last Updated: 2018-10-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
163 participants
OBSERVATIONAL
2018-05-30
2018-09-30
Brief Summary
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Our research hypothesis is that hyperoxia before cardiac arrest aggravates myocardial damage, secondly we wish to analyze the association between hyperoxia after cardiac arrest and myocardial injury.
The exposure variables is oxygenation within 48 hours before and 48 hours after cardiac arrest, our primary outcome is myocardial damage and will be measured as peak troponin within 30 days after cardiac arrest.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Hypoxia
Defined as a group of patients with oxygen saturation \<94 % irrespective of supplemental oxygen.
If COPD, defined as oxygen saturation \<88 % irrespective of supplemental oxygen.
Oxygenation
Oxygenation measured as oxygen supply and saturation before cardiac arrest, and oxygenation measured as PaO2 after cardiac arrest.
Normoxia
Defined as a group of patients with oxygen saturation 94 % - 98 % in combination of supplemental oxygen, or oxygen saturation \>94 % without supplemental oxygen.
If COPD, defined as oxygen saturation 88 % - 92 % in combination of supplemental oxygen, or oxygen saturation \>88 % without supplemental oxygen.
Oxygenation
Oxygenation measured as oxygen supply and saturation before cardiac arrest, and oxygenation measured as PaO2 after cardiac arrest.
Hyperoxia
Defined as a group of patients with oxygen saturation \>98 % in combination of supplemental oxygen.
If COPD, defined as oxygen saturation \>92 % in combination of supplemental oxygen.
Oxygenation
Oxygenation measured as oxygen supply and saturation before cardiac arrest, and oxygenation measured as PaO2 after cardiac arrest.
Interventions
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Oxygenation
Oxygenation measured as oxygen supply and saturation before cardiac arrest, and oxygenation measured as PaO2 after cardiac arrest.
Eligibility Criteria
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Inclusion Criteria
* With a record of ICD-10 diagnosis of cardiac arrest in 2014, admitted to a hospital in the Capital Region of Denmark.
* First recorded cardiac arrest in 2014
* Admitted to ICU
* Serum troponin measured within 7 days after cardiac arrest
Exclusion Criteria
* In of hospital cardiac arrest, IHCA, but with no registered saturation before cardiac arrest.
18 Years
ALL
No
Sponsors
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University Hospital Bispebjerg and Frederiksberg
OTHER
Responsible Party
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Kathrine Schmidt Groenbek
Research Assistant, Bispebjerg Hospital.
Locations
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Bispebjerg Hospital
Copenhagen, , Denmark
Countries
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Other Identifiers
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HyperoxiaandCardiacarrest
Identifier Type: -
Identifier Source: org_study_id
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