A Neuropsychological Characterization of Social Feedback Processing in Social Anxiety

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

58 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-03-02

Study Completion Date

2018-10-23

Brief Summary

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The purpose of this study is to characterize neuropsychological mechanisms (positive affect, negative affect and self-evaluation) mediating processing of social feedback in people with different levels of social anxiety, by implementing functional and structural MRI.

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Detailed Description

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Social anxiety (SA) disorder is a relatively widespread emotional disorder which is associated with considerable impairment in social, educational, and occupational functioning (Kessler et al., 2005). This condition is characterized by a debilitating preoccupation with the evaluation of the self by others, ultimately leading to excessive fear and avoidance of interpersonal encounters. As opposed to healthy individuals who typically process social feedback in a positively biased manner, Individuals with high levels of SA tend to evaluate the feedback conveyed by others negatively. Such biases have a profound contribution to the maintenance of social-related concerns (Clark \& Wells, 1995).

Thus, the overreaching goal of this research is to provide a neuropsychological account of biased processing of social feedback evident in SA. To meet this goal, participants varying in their level of SA are asked to deliver a speech and evaluate it before and after receiving social feedback during an fMRI scan. Additional structural and resting-state fMRI scans, as well as physiological and psychological measures, are obtained throughout the experiment in order to explain individual differences in processing of feedback. fMRI tasks probing basic neuropsychological processes include a self-referential paradigm, wherein participants judge if different traits varying in valence and social domain (power vs. affiliation) are descriptive of them; a reward vs. punishment task, in which participants can win or lose money; and an emotional reactivity task, in which participants view faces with different emotional expressions.

The long-term goal of this study is to better delineate both neurobiological and psychological models of SA, as well as to help in directing future neuromodulation-based treatments of mood and anxiety disorders.

Conditions

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Social Anxiety

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Study group

social feedback and neuropsychological assessment

Group Type EXPERIMENTAL

Social feedback

Intervention Type BEHAVIORAL

Social feedback regarding performance of a public speech is delivered to participants

Self-referential paradigm

Intervention Type BEHAVIORAL

Exposure to traits varying in valence (positive vs. negative) and social domain (power vs. affiliation)

Reward vs. punishment task

Intervention Type BEHAVIORAL

Reception of monetary gains vs. losses

Emotional reactivity task

Intervention Type BEHAVIORAL

Exposure to emotional faces vs. shapes

Interventions

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Social feedback

Social feedback regarding performance of a public speech is delivered to participants

Intervention Type BEHAVIORAL

Self-referential paradigm

Exposure to traits varying in valence (positive vs. negative) and social domain (power vs. affiliation)

Intervention Type BEHAVIORAL

Reward vs. punishment task

Reception of monetary gains vs. losses

Intervention Type BEHAVIORAL

Emotional reactivity task

Exposure to emotional faces vs. shapes

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Healthy participants
* With different levels of social anxiety as measured by the Liebowitz Social Anxiety Scale-Self-Report (LSAS-SR; Fresco et al., 2001)
* Normal or corrected-to-normal vision
* Compatibility with general MRI requirements