CART-19 FOR Relapsed/Refractory Acute Lymphoblastic Leukemia （ALL）

NCT ID: NCT03544021

Last Updated: 2018-06-04

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-03-01
• Study Completion Date: 2020-03-01

Brief Summary

The purpose of this study is to evaluate the safety and efficiency of CD19-Targeted CAR-T in Treating Patients with relapsed/refractory acute leukemia.

Detailed Description

The relapsed/refractory ALL patients will receive FC (F,Fludarabine，C，Cyclophosphamide) chemotherapy followed by infusion of allogenic or autologous CD19-Targeted CAR-T cells.No graft-versus-host disease (GVHD) prevention will be conducted before or after infusion. Dose-limiting toxicity,incidence of adverse events and disease response will be detected post-infusion.

Conditions

Leukemia, Lymphocytic, Acute

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

CART-19

The relapsed/refractory ALL patients will receive allogenic or autologous CD19-Targeted CAR-T cells infusion after FC chemotherapy.

Group Type: EXPERIMENTAL

CART-19 cells

Intervention Type: BIOLOGICAL

CD19-Targeted CAR-T cells are infused to patient received FC chemotherapy

Interventions

CART-19 cells

CD19-Targeted CAR-T cells are infused to patient received FC chemotherapy

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

• CD19-expressing ALL must be assured and must be relapsed or refractory disease. According to current traditional therapies, there must be no available alternative curative therapies and subjects must be either ineligible for allogeneic stem cell transplant (SCT), have refused SCT, or have disease activity that prohibits SCT at this time.
• Estimated life expectancy ≥ 12 weeks (according to investigator's judgment)
• Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2
• CD19 expression of the malignant cells must be detected by immunohistochemistry or by flow cytometry
• Patients must have measurable or evaluable disease at the time of enrollment, which may include any evidence of disease including minimal residual disease detected by flow cytometry, cytogenetics, or polymerase chain reaction (PCR) analysis.
• Patients must have an healthy donor for T cells.
• Cardiac function: Left ventricular ejection fraction greater than or equal to 40% by MUGA or cardiac MRI, or fractional shortening greater than or equal to 28% by ECHO or left ventricular ejection fraction greater than or equal to 50% by ECHO.
• Renal function: Creatinine level of peripheral blood is required no greater than 133umol/L.
• Females of child-bearing potential must have a negative pregnancy test because of the potentially dangerous effects on the fetus.
• Patients with history of allogeneic stem cell transplantation are eligible if there is no evidence of active GVHD and no longer taking immunosuppressive agents for at least 30 days prior to enrollment.
• Ability to give informed consent.

Exclusion Criteria

• Evident signs suggesting that patients are potentially allergic to cytokines.
• Frequent infection history and recent infection is uncontrolled.
• Patients with concomitant genetic syndrome: patients with Down syndrome, Fanconi anemia, Kostmann syndrome, Shwachman syndrome or any other known bone marrow failure syndrome.
• Active acute or chronic graft-versus-host disease (GVHD) or requirement of immunosuppressant medications for GVHD within 4 weeks of enrollment.
• Concurrent use of systemic steroids or chronic use of immunosuppressant medications. Recent or current use of inhaled steroids is not exclusionary. For additional details regarding use of steroid and immunosuppressant medications.
• Pregnancy and nursing females.
• HIV infection.
• Active hepatitis B or active hepatitis C.
• Participation in a prior investigational study within 4 weeks prior to enrollment or longer if required by local regulation. Participation in non-therapeutic research studies is allowed.
• Patients with a known history or prior diagnosis of other serious immunologic, malignant or inflammatory disease.
• Other situations we think not eligible for participation in the research.

• Minimum Eligible Age: 14 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The Affiliated Hospital of the Chinese Academy of Military Medical Sciences

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

HUISHENG AI

Role: STUDY_CHAIR

307 Hospital of PLA

Locations

307 Hospital of PLA

Beijing, Beijing 100071, China

Site Status: RECRUITING

Countries

China

Central Contacts

HUISHENG AI

Role: CONTACT

HUISHNGAI@163.COM

8610-66947126

MEI GUO

Role: CONTACT

8610-66947135

Facility Contacts

Huisheng Ai, MD

Role: primary

huishengai@163.com

86-1066947126

Other Identifiers

CART-19 FOR ALL

Identifier Type: -

Identifier Source: org_study_id