Allogeneic CART-19 for Elderly Relapsed/Refractory CD19+ ALL
NCT ID: NCT02799550
Last Updated: 2019-02-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE1
10 participants
INTERVENTIONAL
2015-10-31
2020-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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allogeneic CART-19
infusions of allogeneic CD19-directed chimeric antigen receptor-modified T cells (CART-19)
allogeneic CART-19
allogeneic CD19-directed chimeric antigen receptor-modified T cells (CART-19)
Interventions
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allogeneic CART-19
allogeneic CD19-directed chimeric antigen receptor-modified T cells (CART-19)
Eligibility Criteria
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Inclusion Criteria
* Patient with relapsed and/or refractory CD19 positive B-cell acute lymphoblastic leukemia (B-ALL)
* Estimated life expectancy ≥ 12 weeks (according to investigator's judgment)
* Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2
Exclusion Criteria
* CD19 negative B-cell leukemia
* Any uncontrolled active medical disorder that would preclude participation as outlined
60 Years
ALL
No
Sponsors
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Chinese PLA General Hospital
OTHER
The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
OTHER
Responsible Party
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Principal Investigators
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Huisheng Ai, MD
Role: STUDY_CHAIR
Affiliated Hospital of Academy of Military Medical Sciences
Locations
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Affiliated Hospital of Academy of Military Medical Sciences ,
Beijing, Beijing 100071, China
Chinese PLA General Hospital
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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Facility Contacts
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References
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Cai B, Guo M, Wang Y, Zhang Y, Yang J, Guo Y, Dai H, Yu C, Sun Q, Qiao J, Hu K, Zuo H, Dong Z, Zhang Z, Feng M, Li B, Sun Y, Liu T, Liu Z, Wang Y, Huang Y, Yao B, Han W, Ai H. Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia. J Hematol Oncol. 2016 Nov 25;9(1):131. doi: 10.1186/s13045-016-0357-z.
Other Identifiers
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CART-ALL-2015
Identifier Type: -
Identifier Source: org_study_id
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