Oxidation-reduction Homeostasis in Cognitive Impairment Patients After Stroke

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-03-01

Study Completion Date

2019-01-01

Brief Summary

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Cognitive impairment after ischemic stroke can affect not only the social adaptation ability, but also affect the comprehensive rehabilitation of patients. The damage of cognitive impairment after ischemic stroke is not lower than the body function defect after stroke. Many studies have shown that oxidative stress is one of the pathophysiological mechanisms of ischemic cerebrovascular disease. Many studies have reported that the oxidative-reduction of cells plays an important role in the life activities of organisms, affecting the health, aging and death of the organism. In the recent years, some scholars have suggested that post-stroke cognitive impairment may be related to oxidative-reduction homeostasis of the body, but the relevant evidence is lacking and needs to be further explored. Therefore, the purpose of this study is to explore the effect of oxidation-reduction homeostasis on cognitive impairment in patients with ischemic stroke, and provide a theoretical basis for the prevention and treatment of cognitive impairment after ischemic stroke.

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Detailed Description

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Conditions

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Oxidative-reduction Homeostasis Post-stroke Cognitive Impairment

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patients with post-stroke cognitive impairment

No intervention has been conducted

Intervention Type OTHER

It is an observational study, and no intervention has been conducted

Patients without post-stroke cognitive impairment

No intervention has been conducted

Intervention Type OTHER

It is an observational study, and no intervention has been conducted

Interventions

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No intervention has been conducted

It is an observational study, and no intervention has been conducted

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 40-80 years old;
* Ischemic stroke for the first time or previous stroke but with no serious sequelae (mRS is 0 -2 points);
* Time from onset to treatment ≤48 hours;
* Conscious awareness, and with no obvious aphasia and visual impairment;
* Signed informed consent by patient self or legally authorized representatives.

Exclusion Criteria

* Intracranial hemorrhage or suspected subarachnoid hemorrhage;
* Transient ischemic attack;
* Patients with severe mental disorders or language disorders;
* Patients can not cooperate with evaluators, such as mental illness or dementia;
* Pregnant women or suckers;
* Researchers consider patients inappropriate to participate in the registry.

Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No