Human Vasodilatory Effect of GLP-1

NCT ID: NCT03502083

Last Updated: 2018-04-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

11 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-12-01

Study Completion Date

2017-03-01

Brief Summary

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Comprehensive assessment of human vasodilatory effect of GLP-1 in forearm and coronary arteries

Detailed Description

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Conditions

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Coronary Stenosis Type2 Diabetes Angina, Stable

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Interventions

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GLP-1 (7-36)Amide

IV infusion

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Waiting list for elective PCI to LAD Able to give informed consent Over 18

Exclusion Criteria

* GLP-1 based therapy Insulin Calcium channel blockers Nicorandil Nitrates
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Papworth Hospital NHS Foundation Trust

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

References

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Aetesam-Ur-Rahman M, Zhao TX, Paques K, Oliveira J, Khialani B, Kyranis S, Braganza DM, Clarke SC, Bennett MR, West NEJ, Hoole SP. Coronary Flow Variations Following Percutaneous Coronary Intervention Affect Diastolic Nonhyperemic Pressure Ratios More Than the Whole Cycle Ratios. J Am Heart Assoc. 2022 May 3;11(9):e023554. doi: 10.1161/JAHA.121.023554. Epub 2022 Apr 26.

Reference Type DERIVED
PMID: 35470686 (View on PubMed)

Aetesam-Ur-Rahman M, Giblett JP, Khialani B, Kyranis S, Clarke SJ, Zhao TX, Braganza DM, Clarke SC, West NEJ, Bennett MR, Hoole SP. GLP-1 vasodilatation in humans with coronary artery disease is not adenosine mediated. BMC Cardiovasc Disord. 2021 May 1;21(1):223. doi: 10.1186/s12872-021-02030-5.

Reference Type DERIVED
PMID: 33932990 (View on PubMed)

Other Identifiers

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14/EE/0018

Identifier Type: -

Identifier Source: org_study_id

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