Fujifilm DBT Plus S-View Versus FFDM Alone in the Detection of Breast Cancer - A Pivotal Study

NCT ID: NCT03501693

Last Updated: 2023-09-21

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-04-06

Study Completion Date

2018-08-31

Brief Summary

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The purpose of the pivotal reader study is to assess the comparative accuracy of Fujifilm DBT plus S-View versus FFDM in the detection of breast cancer.

Detailed Description

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This clinical research is a retrospective, pivotal, multi-reader, multi-case (MRMC) study with an enriched sample of 300 breast screening or diagnostic cases which were selected from the library of mammograms collected under Fujifilm protocol FMSU2013-004A (all subjects previously provided written informed consent agreeing their image data and supporting documentation could be used for future research and investigations). Approximately 18 qualified radiologists will independently perform two reads on all (approximately 300) cases. Each reader will read each case both as a FFDM read, and a DBT plus S-View read on the ASPIRE Bellus II workstation.

As its primary endpoint, this study is designed to evaluate whether the area under the receiver operating characteristic (ROC) curve (AUC) based on probability of malignancy (POM) scores and requiring correct lesion localization is statistically non-inferior for DBT plus S-View versus FFDM.

Conditions

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Breast Cancer

Study Design

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Observational Model Type

CASE_CROSSOVER

Study Time Perspective

RETROSPECTIVE

Study Groups

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DBT plus S-View

Breast images utilizing DBT plus S-View

DBT plus S-View

Intervention Type DEVICE

DBT plus S-View images

FFDM alone

FFDM alone images

FFDM Alone

Intervention Type DEVICE

FFDM alone images

Interventions

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DBT plus S-View

DBT plus S-View images

Intervention Type DEVICE

FFDM Alone

FFDM alone images

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* •Female subjects participating in FMSU2013-004A protocol with known clinical status

Exclusion Criteria

* •Female subjects that did not have known clinical status in FMSU2013-004A
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Fujifilm Medical Systems USA, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Robert M Uzenoff

Role: STUDY_DIRECTOR

Fujifilm Medical Systems USA, Inc.

Locations

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International HealthCare, LLC

Norwalk, Connecticut, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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FMSU2017-002B

Identifier Type: -

Identifier Source: org_study_id

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